HitPredict

Interactor 1: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Interactor 2: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane GO:0042475 - odontogenesis of dentin-containing tooth
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1089 Hs			1 595
+	Hs
		557299 PGFRA_HUMAN (1-1089): 0: 817: 100.00		FARP1_HUMAN (2-526): 5.38e-114: 366: 18.35
+	Hs
		452499 PGFRB_HUMAN (29-1089): 0: 650: 43.33		FARP1_HUMAN (2-526): 5.38e-114: 366: 18.35
+	Hs
		609192 FGFR3_HUMAN (745-969): 1.84e-76: 270: 40.74		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		505551 FGFR3_HUMAN (745-969): 1.84e-76: 270: 40.74		EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73
+	Hs
		299238 FGFR3_HUMAN (745-969): 1.84e-76: 270: 40.74		FARP2_HUMAN (3-537): 6.42e-112: 360: 17.89
+	Hs
		434144 RET_HUMAN (573-690): 7.85e-22: 104: 43.22		MERL_HUMAN (1-595): 1.12e-172: 504: 100.00
+	Hs
		607900 FGFR4_HUMAN (3-221): 4.21e-22: 104: 8.36		MERL_HUMAN (1-595): 1.12e-172: 504: 100.00
+	Hs
		1083898 NTRK2_HUMAN (48-776): 2.93e-51: 197: 14.04		E41L5_HUMAN (2-595): 6.77e-134: 410: 18.38
+	Mm
		546328 NTRK2_MOUSE (53-776): 3.36e-53: 202: 13.62		E41L3_MOUSE (14-544): 5.06e-116: 368: 20.89
+	Hs
		546928 FGFR4_HUMAN (3-221): 4.21e-22: 104: 8.36		EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20
+	Hs
		434145 RET_HUMAN (573-690): 7.85e-22: 104: 43.22		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		607901 FGFR4_HUMAN (3-221): 4.21e-22: 104: 8.36		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		719673 VGFR3_HUMAN (128-609): 7.49e-19: 94.9: 11.28		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		607883 FGFR4_HUMAN (3-221): 4.21e-22: 104: 8.36		MOES_HUMAN (19-595): 5.97e-146: 435: 44.44
+	Hs
		640055 VGFR3_HUMAN (128-609): 7.49e-19: 94.9: 11.28		MOES_HUMAN (19-595): 5.97e-146: 435: 44.44
+	Mm
		1206834 PTK7_MOUSE (214-571): 9.03e-35: 146: 15.22		E41L3_MOUSE (14-544): 5.06e-116: 368: 20.89
+	Hs
		505564 UFO_HUMAN (13-225): 2.38e-15: 83.4: 14.71		EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73
+	Hs
		674528 UFO_HUMAN (13-225): 2.38e-15: 83.4: 14.71		E41L1_HUMAN (1-535): 3.42e-120: 378: 21.61
+	Hs
		204618 UFO_HUMAN (13-225): 2.38e-15: 83.4: 14.71		E41L2_HUMAN (11-519): 9e-113: 361: 19.70
+	Dm
		112241 M9MRE1_DROME (20-534): 4.38e-44: 176: 17.11		Q9W0R3_DROME (30-311): 1.01e-26: 117: 29.39