Protein: KPYR
Pyruvate kinase PKLR (EC 2.7.1.40) (Pyruvate kinase 1) (Pyruvate kinase isozymes L/R) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase)

Gene: KPYR, PKLR
Organism: Homo sapiens
Interactions: 50
UniProt ID: P30613

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001666 - response to hypoxia
GO:0004743 - pyruvate kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

573005

KPYM
Pyruvate kinase PKM

1

14

High-throughput

0.665

High

720863

KPYR
Pyruvate kinase PKLR

1

14

High-throughput

0.618

High

720894

CPNE7
Copine-7

2

1

High-throughput

0.606

High

158403

RFXK
DNA-binding protein RFXANK

1

2

High-throughput

0.536

High

251714

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

1

High-throughput

0.536

High

720864

CLIP1
CAP-Gly domain-containing linker protein 1

1

2

High-throughput

0.536

High

720889

OTUD5
OTU domain-containing protein 5

1

1

High-throughput

0.536

High

720897

SRPK3
SRSF protein kinase 3

1

5

High-throughput

0.536

High

720900

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

224468

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.513

High

720881

SPIN4
Spindlin-4

1

0

High-throughput

0.513

High

720888

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

0

High-throughput

0.513

High

720891

CMA1A
Ciliary microtubule associated protein 1A

1

0

High-throughput

0.513

High

720899

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.513

High

720879

ISX
Intestine-specific homeobox

1

2

High-throughput

0.489

High

720880

PCGF3
Polycomb group RING finger protein 3

1

4

High-throughput

0.489

High

720885

RSLBA
Ras-like protein family member 11A

1

2

High-throughput

0.489

High

550873

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.480

High

159524

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

3

High-throughput

0.479

High

519776

ANDR
Androgen receptor

1

3

Small-scale

0.479

High

720866

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

High-throughput

0.479

High

720867

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

720872

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

5

Small-scale

0.479

High

720873

KIF23
Kinesin-like protein KIF23

1

2

Small-scale

0.479

High

720874

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.479

High

720875

PAK1
Serine/threonine-protein kinase PAK 1

1

3

Small-scale

0.479

High

720876

CUL4A
Cullin-4A

1

5

High-throughput

0.479

High

720878

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

720887

TRI72
Tripartite motif-containing protein 72

1

3

Small-scale

0.479

High

720893

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

720896

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

165120

RASM
Ras-related protein M-Ras

1

2

High-throughput

0.470

High

720868

PAXI
Paxillin

1

0

Small-scale

0.458

High

720870

SPS1
Selenide, water dikinase 1

1

0

High-throughput

0.458

High

720877

ARHG6
Rho guanine nucleotide exchange factor 6

1

0

Small-scale

0.458

High

720892

SAV1
Protein salvador homolog 1

1

7

Small-scale

0.457

High

402863

ANXA1
Annexin A1

1

1

Small-scale

0.445

High

720869

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

720871

EFNA3
Ephrin-A3

1

1

High-throughput

0.437

High

720898

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

High-throughput

0.437

High

720883

NT5D1
5'-nucleotidase domain-containing protein 1

2

0

High-throughput

0.318

High

553419

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

0

High-throughput

0.279

Low

720865

S5A2
3-oxo-5-alpha-steroid 4-dehydrogenase 2

1

0

High-throughput

0.279

Low

720882

TMM69
Transmembrane protein 69

1

0

High-throughput

0.279

Low

720884

USPL1
SUMO-specific isopeptidase USPL1

1

0

High-throughput

0.279

Low

720890

LRC3B
Leucine-rich repeat-containing protein 3B

1

0

High-throughput

0.279

Low

720895

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.279

Low

564692

CP4B1
Cytochrome P450 4B1

1

0

High-throughput

0.269

Low

720886

CLC4G
C-type lectin domain family 4 member G

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025