Protein: SHC4
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)

Gene: SHC4
Organism: Homo sapiens
Interactions: 21
UniProt ID: Q6S5L8

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0006915 - apoptotic process
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
GO:0008284 - positive regulation of cell population proliferation
GO:0010468 - regulation of gene expression

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

338577

EGFR
Epidermal growth factor receptor

6

20

Small-scale

0.952

High

1164327

SHC3
SHC-transforming protein 3

2

19

High-throughput

0.789

High

924646

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.754

High

441524

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

499274

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

972337

TIE2
Angiopoietin-1 receptor

1

20

Small-scale

0.692

High

383859

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

601938

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

1070976

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

385029

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.618

High

985979

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.618

High

1083860

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.618

High

1164326

NBEA
Neurobeachin

2

4

High-throughput

0.611

High

1164329

GARE1
GRB2-associated and regulator of MAPK protein 1

2

6

High-throughput

0.611

High

167568

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

2

18

High-throughput

0.558

High

570633

DCAM
S-adenosylmethionine decarboxylase proenzyme

2

3

High-throughput

0.558

High

487535

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

1164328

NUAK2
NUAK family SNF1-like kinase 2

1

1

High-throughput

0.536

High

434220

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.527

High

610438

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

1063883

TNIP1
TNFAIP3-interacting protein 1

1

17

High-throughput

0.437

High


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Last updated: 15 Jul 2024