HitPredict

Interactor 1: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Interactor 2: GDF15 (Q99988)
Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)
Gene: GDF15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0042803 - protein homodimerization activity GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1089 Hs			1 308
+	Hs
		557027 PGFRA_HUMAN (1-1089): 0: 817: 100.00		BMP7_HUMAN (21-307): 4.37e-76: 240: 17.69
+	Hs
		557049 PGFRA_HUMAN (1-1089): 0: 817: 100.00		BMP8B_HUMAN (21-307): 6.45e-67: 216: 19.61
+	Hs
		557176 PGFRA_HUMAN (1-1089): 0: 817: 100.00		BMP8A_HUMAN (21-307): 4.96e-66: 214: 19.94
+	Hs
		351245 PGFRA_HUMAN (1-1089): 0: 817: 100.00		TGFB1_HUMAN (33-307): 7.59e-61: 200: 21.48
+	Hs
		557082 PGFRA_HUMAN (1-1089): 0: 817: 100.00		INHBE_HUMAN (165-307): 3.07e-43: 153: 28.86
+	Hs
		1081583 NTRK3_HUMAN (28-227): 3.23e-13: 76.1: 9.01		GDF15_HUMAN (1-308): 6.47e-102: 302: 100.00