HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	12214271, 16966330
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005783 - endoplasmic reticulum GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 1356
+	Hs
		452344 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45
+	Hs
		499225 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		KIT_HUMAN (15-545): 5.99e-49: 192: 17.46
+	Hs
		208979 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45
+	Hs
		208982 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		KIT_HUMAN (15-545): 5.99e-49: 192: 17.46
+	Hs
		507832 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FGFR1_HUMAN (1-169): 8.34e-17: 88.1: 13.54
+	Hs
		557606 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FGFR4_HUMAN (538-817): 2.68e-15: 83.5: 14.42
+	Mm
		643062 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		RET_MOUSE (809-1201): 1.5e-77: 281: 41.01
+	Hs
		557624 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		VGFR3_HUMAN (1-123): 1.31e-13: 78.1: 14.93
+	Hs
		208983 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		FGFR1_HUMAN (1-169): 8.34e-17: 88.1: 13.54
+	Hs
		208993 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		FGFR4_HUMAN (538-817): 2.68e-15: 83.5: 14.42
+	Hs
		452370 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45
+	Hs
		499242 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		KIT_HUMAN (15-545): 5.99e-49: 192: 17.46
+	Hs
		499244 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		KIT_HUMAN (15-545): 5.99e-49: 192: 17.46
+	Hs
		499264 GRAP_HUMAN (5-251): 9.35e-27: 107: 20.00		KIT_HUMAN (15-545): 5.99e-49: 192: 17.46
+	Hs
		738170 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		FLT3_HUMAN (40-555): 7.17e-20: 98.5: 16.22
+	Hs
		507897 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		FGFR1_HUMAN (1-169): 8.34e-17: 88.1: 13.54
+	Hs
		607907 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		FGFR4_HUMAN (538-817): 2.68e-15: 83.5: 14.42
+	Mm
		403533 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		KIT_MOUSE (2-431): 1.95e-25: 116: 13.01
+	Mm
		404009 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		PGFRB_MOUSE (1-516): 1.05e-22: 107: 13.40
+	Mm
		452179 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		CSF1R_MOUSE (458-821): 1.83e-18: 93.9: 12.14