Protein: CYC8
General transcriptional corepressor CYC8 (Glucose repression mediator protein CYC8)

Gene: CYC8
Organism: Saccharomyces cerevisiae S288C
Interactions: 89
UniProt ID: P14922

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000278 - mitotic cell cycle
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

577522

TUP1
General transcriptional corepressor TUP1

21

16

Small-scale

0.767

High

577533

MIG1
Regulatory protein MIG1

5

9

Small-scale

0.708

High

577582

CTI6
Histone deacetylase complex subunit CTI6

3

1

Small-scale

0.670

High

577575

NRG1
Transcriptional regulator NRG1

3

15

Small-scale

0.665

High

577519

CYC8
General transcriptional corepressor CYC8

1

11

Small-scale

0.647

High

577573

SKO1
CRE-binding bZIP protein SKO1

3

0

Small-scale

0.634

High

577541

RGT1
Glucose transport transcription regulator RGT1

3

0

Small-scale

0.633

High

577566

HOS2
Probable histone deacetylase HOS2

2

10

Small-scale

0.623

High

577539

RPD3
Histone deacetylase RPD3

2

11

Small-scale

0.618

High

444413

DED1
ATP-dependent RNA helicase DED1

1

6

Small-scale

0.618

High

577565

SUT1
Sterol uptake protein 1

2

0

Small-scale

0.605

High

577563

RFX1
RFX-like DNA-binding protein RFX1

2

0

Small-scale

0.591

High

577521

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

3

Small-scale

0.584

High

408456

GAL80
Galactose/lactose metabolism regulatory protein GAL80

2

0

Small-scale

0.577

High

577538

HIR1
Protein HIR1

1

12

Small-scale

0.573

High

525819

HSP72
Heat shock protein SSA2

2

15

Small-scale

0.571

High

577530

MAS5
Mitochondrial protein import protein MAS5

2

15

Small-scale

0.571

High

577525

OPI1
Transcriptional repressor OPI1

2

0

Small-scale

0.569

High

577551

UME6
Transcriptional regulatory protein UME6

2

0

Small-scale

0.569

High

577561

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

9

Small-scale

0.561

High

577555

MED3
Mediator of RNA polymerase II transcription subunit 3

1

0

Small-scale

0.557

High

577526

AFT1
Iron-regulated transcriptional activator AFT1

1

0

Small-scale

0.537

High

577523

SFL1
Flocculation suppression protein

1

1

Small-scale

0.527

High

577547

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

5

High-throughput

0.515

High

577586

HOS1
Histone deacetylase HOS1

1

10

Small-scale

0.515

High

577584

MED2
Mediator of RNA polymerase II transcription subunit 2

1

0

Small-scale

0.513

High

577588

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

Small-scale

0.513

High

577570

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

9

High-throughput

0.508

High

577574

CUS1
Cold sensitive U2 snRNA suppressor 1

1

1

High-throughput

0.508

High

577546

RTG3
Retrograde regulation protein 3

1

0

Small-scale

0.504

High

577527

URE2
Transcriptional regulator URE2

1

3

Small-scale

0.501

High

577528

ROX1
Repressor ROX1

1

13

Small-scale

0.501

High

577531

DAL80
Nitrogen regulatory protein DAL80

1

6

Small-scale

0.501

High

577543

YOX1
Homeobox protein YOX1

1

7

Small-scale

0.501

High

577579

YHP1
Homeobox protein YHP1

1

4

Small-scale

0.501

High

577536

BEM1
Bud emergence protein 1

1

5

High-throughput

0.494

High

577548

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

7

High-throughput

0.494

High

577587

SMT3
Ubiquitin-like protein SMT3

1

4

High-throughput

0.481

High

454385

PHO4
Phosphate system positive regulatory protein PHO4

1

0

Small-scale

0.480

High

515406

HMAL2
Silenced mating-type protein ALPHA2

1

0

Small-scale

0.480

High

577532

INO2
Protein INO2

1

0

Small-scale

0.480

High

577558

HAC1
Transcriptional activator HAC1

1

0

Small-scale

0.480

High

577568

MOT3
Transcriptional activator/repressor MOT3

1

0

Small-scale

0.480

High

403333

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

5

Small-scale

0.479

High

434779

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

577529

SIS1
Protein SIS1

1

16

High-throughput

0.479

High

577544

DEF1
RNA polymerase II degradation factor 1

1

7

High-throughput

0.479

High

577556

YAP4
AP-1-like transcription factor YAP4

1

1

Small-scale

0.479

High

577557

GTS1
Protein GTS1

1

1

Small-scale

0.479

High

577559

CUP9
Homeobox protein CUP9

1

1

Small-scale

0.479

High

577560

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

6

High-throughput

0.479

High

577571

NOP3
Serine/arginine

1

12

Small-scale

0.479

High

577576

GCN5
Histone acetyltransferase GCN5

1

13

Small-scale

0.479

High

577577

YAP6
AP-1-like transcription factor YAP6

1

1

Small-scale

0.479

High

577580

SIZ1
E3 SUMO-protein ligase SIZ1

1

4

High-throughput

0.479

High

577590

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

12

Small-scale

0.479

High

577553

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

577535

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

577545

PHD1
Putative transcription factor PHD1

1

0

Small-scale

0.458

High

577549

SDO1L
Restriction of telomere capping protein 3

1

0

High-throughput

0.458

High

577550

SKN7
Transcription factor SKN7

1

0

Small-scale

0.458

High

577578

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

577583

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

522932

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.445

High

543684

SSB1
Ribosome-associated molecular chaperone SSB1

1

15

High-throughput

0.445

High

577540

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

577552

CAJ1
Protein CAJ1

1

20

High-throughput

0.445

High

577554

SSB2
Ribosome-associated molecular chaperone SSB2

1

15

High-throughput

0.445

High

577567

APJ1
J domain-containing protein APJ1

1

16

High-throughput

0.445

High

577589

GDIR
Rho GDP-dissociation inhibitor

1

1

High-throughput

0.439

High

394182

EF1A
Elongation factor 1-alpha

1

3

Small-scale

0.437

High

454837

RS19A
Small ribosomal subunit protein eS19A

1

2

Small-scale

0.437

High

455370

RS19B
Small ribosomal subunit protein eS19B

1

2

Small-scale

0.437

High

513621

RL2A
Large ribosomal subunit protein uL2A

1

2

Small-scale

0.437

High

569893

RL3
Large ribosomal subunit protein uL3

1

2

Small-scale

0.437

High

571339

CPYI
Carboxypeptidase Y inhibitor

1

2

High-throughput

0.437

High

577520

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

Small-scale

0.437

High

577524

SAR1
Small COPII coat GTPase SAR1

1

2

Small-scale

0.437

High

577537

ACH1
Acetyl-CoA hydrolase

1

1

Small-scale

0.437

High

577542

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.437

High

577569

PURA
Adenylosuccinate synthetase

1

1

Small-scale

0.437

High

577021

SEC63
Protein translocation protein SEC63

1

20

High-throughput

0.407

High

577534

ERV1
Mitochondrial FAD-linked sulfhydryl oxidase ERV1

1

0

Small-scale

0.261

Low

577562

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

577564

PSP2
Protein PSP2

1

0

Small-scale

0.249

Low

577572

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

577581

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low

577585

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025