HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: DCC (P43146)
Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC)
Gene: DCC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12149262
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 1447
+	Hs
		297883 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		NFASC_HUMAN (33-716): 1.87e-86: 312: 21.52
+	Dm
		337644 ABL_DROME (7-123): 1.59e-12: 71.3: 26.89		LAR_DROME (3-1433): 9.39e-120: 417: 16.85
+	Mm
		56907 FYN_MOUSE (7-173): 7.13e-21: 96: 15.39		PTPRF_MOUSE (333-1447): 2.08e-108: 382: 16.55
+	Hs
		412016 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		PTPRD_HUMAN (330-1347): 8.81e-108: 380: 16.11
+	Hs
		234472 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		DSCAM_HUMAN (6-706): 2.49e-41: 169: 11.53
+	Hs
		411959 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		PTPRF_HUMAN (6-1282): 3.13e-105: 372: 16.72
+	Hs
		297881 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		NFASC_HUMAN (33-716): 1.87e-86: 312: 21.52
+	Hs
		297885 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		NFASC_HUMAN (33-716): 1.87e-86: 312: 21.52
+	Dm
		219806 NCK_DROME (5-374): 5.6e-68: 225: 42.54		O44924_DROME (37-805): 1.74e-38: 159: 25.06
+	Dm
		53796 ABL_DROME (7-123): 1.59e-12: 71.3: 26.89		A1Z921_DROME (4-728): 2.88e-52: 204: 14.45
+	Dm
		219802 ABL_DROME (7-123): 1.59e-12: 71.3: 26.89		O44924_DROME (37-805): 1.74e-38: 159: 25.06