HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.727

Property	Details
Experiments	12135674, 22974441
Identification Methods	affinity chromatography technology, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007015 - actin filament organization GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 870
+	Hs
		209020 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00
+	Hs
		557691 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		CASL_HUMAN (1-868): 1.02e-91: 309: 35.96
+	Hs
		655289 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00
+	Rn
		1144371 P85A_RAT (241-376): 8.21e-22: 99.1: 19.57		BCAR1_RAT (2-870): 4.08e-103: 343: 89.12
+	Rn
		1144044 FYN_RAT (7-173): 7.13e-21: 96: 15.39		BCAR1_RAT (2-870): 4.08e-103: 343: 89.12
+	Hs
		557670 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ACK1_HUMAN (9-499): 2.55e-30: 131: 15.35
+	Mm
		222878 NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94		ACK1_MOUSE (9-581): 1.34e-29: 128: 13.93
+	Hs
		209039 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		ACK1_HUMAN (9-499): 2.55e-30: 131: 15.35
+	Hs
		199501 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		EFS_HUMAN (4-429): 4.35e-14: 78: 22.56
+	Hs
		203208 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		SYNJ1_HUMAN (281-696): 4.9e-10: 65.7: 13.47
+	Hs
		199489 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		EFS_HUMAN (4-429): 4.35e-14: 78: 22.56
+	Hs
		789093 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		CASS4_HUMAN (4-865): 6.37e-38: 154: 19.91
+	Hs
		655334 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		ACK1_HUMAN (9-499): 2.55e-30: 131: 15.35
+	Hs
		91474 E7ERP6_HUMAN (1-76): 3.94e-36: 128: 78.95		EFS_HUMAN (4-429): 4.35e-14: 78: 22.56
+	Hs
		655439 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		SH3K1_HUMAN (7-294): 1.08e-16: 86.7: 16.44
+	Hs
		3145 A0A0S2Z4E4_HUMAN (1-181): 3.34e-26: 107: 74.87		EFS_HUMAN (4-429): 4.35e-14: 78: 22.56
+	Hs
		199493 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		EFS_HUMAN (4-429): 4.35e-14: 78: 22.56
+	Hs
		199505 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		EFS_HUMAN (4-429): 4.35e-14: 78: 22.56
+	Rn
		192744 SRBS2_RAT (3-162): 4.86e-25: 109: 28.05		SYNJ1_RAT (284-740): 1.09e-09: 64.5: 11.35
+	Hs
		203192 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		SYNJ1_HUMAN (281-696): 4.9e-10: 65.7: 13.47