Protein: PMS2
Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2)

Gene: PMS2
Organism: Homo sapiens
Interactions: 91
UniProt ID: P54278

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0004519 - endonuclease activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

827359

MLH1
DNA mismatch repair protein Mlh1

31

14

Small-scale

0.994

High

846572

MSH2
DNA mismatch repair protein Msh2

3

20

Small-scale

0.827

High

913288

MSH6
DNA mismatch repair protein Msh6

3

20

Small-scale

0.827

High

928725

FAN1
Fanconi-associated nuclease 1

7

6

Small-scale

0.743

High

928707

FANCJ
Fanconi anemia group J protein

6

2

Small-scale

0.735

High

550939

PCNA
Proliferating cell nuclear antigen

3

5

Small-scale

0.651

High

633301

MSH3
DNA mismatch repair protein Msh3

1

20

High-throughput

0.618

High

507723

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

3

High-throughput

0.595

High

186723

P73
Tumor protein p73

2

2

Small-scale

0.594

High

241192

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

798895

BRCA1
Breast cancer type 1 susceptibility protein

2

4

High-throughput

0.584

High

928722

EXO1
Exonuclease 1

2

5

Small-scale

0.584

High

635698

RASA1
Ras GTPase-activating protein 1

1

1

High-throughput

0.541

High

654101

XPA
DNA repair protein complementing XP-A cells

1

2

High-throughput

0.541

High

728131

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

High-throughput

0.541

High

928679

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

3

High-throughput

0.541

High

928684

FANCC
Fanconi anemia group C protein

1

1

High-throughput

0.541

High

928694

SFRP4
Secreted frizzled-related protein 4

1

1

High-throughput

0.541

High

928702

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

1

High-throughput

0.541

High

219942

XRCC3
DNA repair protein XRCC3

1

3

High-throughput

0.536

High

928709

ABCA2
ATP-binding cassette sub-family A member 2

1

1

High-throughput

0.536

High

171062

VP26C
Vacuolar protein sorting-associated protein 26C

1

0

High-throughput

0.518

High

295017

ZN189
Zinc finger protein 189

1

0

High-throughput

0.518

High

928695

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

440459

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.513

High

928697

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.513

High

928713

PAR6A
Partitioning defective 6 homolog alpha

1

0

High-throughput

0.513

High

928718

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

0

High-throughput

0.513

High

928693

FSCN1
Fascin

1

2

Small-scale

0.505

High

928699

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

2

High-throughput

0.494

High

928706

TRMO
tRNA

1

1

High-throughput

0.494

High

446801

NPM
Nucleophosmin

1

0

High-throughput

0.493

High

893771

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

384390

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.480

High

135907

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

3

High-throughput

0.479

High

172614

XPO1
Exportin-1

1

8

High-throughput

0.479

High

325752

UBR5
E3 ubiquitin-protein ligase UBR5

1

1

High-throughput

0.479

High

348436

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

3

High-throughput

0.479

High

413473

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

473879

NFIC
Nuclear factor 1 C-type

1

12

High-throughput

0.479

High

610275

PRS6A
26S proteasome regulatory subunit 6A

1

4

High-throughput

0.479

High

669855

MCM3
DNA replication licensing factor MCM3

1

2

High-throughput

0.479

High

713975

PML
Protein PML

1

7

High-throughput

0.479

High

769829

RFC2
Replication factor C subunit 2

1

4

High-throughput

0.479

High

774821

ARBK2
G protein-coupled receptor kinase 3

1

2

High-throughput

0.479

High

778639

PRS7
26S proteasome regulatory subunit 7

1

3

High-throughput

0.479

High

904265

BRCA2
Breast cancer type 2 susceptibility protein

1

1

High-throughput

0.479

High

910827

IMA1
Importin subunit alpha-1

1

3

High-throughput

0.479

High

921621

COPB
Coatomer subunit beta

1

4

High-throughput

0.479

High

928677

PRS4
26S proteasome regulatory subunit 4

1

2

High-throughput

0.479

High

928678

PRS10
26S proteasome regulatory subunit 10B

1

3

High-throughput

0.479

High

928681

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

928682

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

3

High-throughput

0.479

High

928683

PRKDC
DNA-dependent protein kinase catalytic subunit

1

4

High-throughput

0.479

High

928686

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

2

High-throughput

0.479

High

928687

NFIA
Nuclear factor 1 A-type

1

12

High-throughput

0.479

High

928689

NFIX
Nuclear factor 1 X-type

1

12

High-throughput

0.479

High

928690

IMB1
Importin subunit beta-1

1

2

High-throughput

0.479

High

928700

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

Small-scale

0.479

High

928704

MMS19
MMS19 nucleotide excision repair protein homolog

1

3

High-throughput

0.479

High

928708

FACD2
Fanconi anemia group D2 protein

1

1

Small-scale

0.479

High

928710

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

Small-scale

0.479

High

928714

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

928715

FANCI
Fanconi anemia group I protein

1

1

Small-scale

0.479

High

928716

ATD3A
ATPase family AAA domain-containing protein 3A

1

3

High-throughput

0.479

High

928720

COPG2
Coatomer subunit gamma-2

1

3

High-throughput

0.479

High

928721

XPO7
Exportin-7

1

6

High-throughput

0.479

High

928723

RUVB2
RuvB-like 2

1

3

High-throughput

0.479

High

928724

RUVB1
RuvB-like 1

1

3

High-throughput

0.479

High

928726

COPG1
Coatomer subunit gamma-1

1

3

High-throughput

0.479

High

128886

MEN1
Menin

1

0

High-throughput

0.458

High

903293

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

0

High-throughput

0.458

High

928680

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

928685

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

928691

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

High-throughput

0.458

High

928692

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.458

High

928712

CLSPN
Claspin

1

0

Small-scale

0.458

High

116307

H3BQ24
Fanconi-associated nuclease

1

6

High-throughput

0.445

High

928696

ARMC6
Armadillo repeat-containing protein 6

1

1

High-throughput

0.445

High

76622

B4DZK1
cDNA FLJ50036, weakly similar to Myosin-11

1

5

High-throughput

0.439

High

928688

TRI29
Tripartite motif-containing protein 29

1

1

Small-scale

0.437

High

928698

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

928705

PSD2
PH and SEC7 domain-containing protein 2

1

3

High-throughput

0.437

High

928711

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

928717

PSD3
PH and SEC7 domain-containing protein 3

1

3

High-throughput

0.437

High

928719

CC180
Coiled-coil domain-containing protein 180

1

5

High-throughput

0.417

High

437652

HEPS
Serine protease hepsin

1

2

High-throughput

0.407

High

928701

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.407

High

928703

FRMD6
FERM domain-containing protein 6

1

3

High-throughput

0.407

High

105632

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

329238

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025