HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: CASL (Q14511)
Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]
Gene: NEDD9

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	8879209
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction and 1 others more... GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 834
+	Hs
		412193 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		CASL_HUMAN (1-834): 0: 614: 100.00
+	Hs
		557645 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		BCAR1_HUMAN (1-832): 3e-84: 289: 33.44
+	Hs
		209020 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		BCAR1_HUMAN (1-832): 3e-84: 289: 33.44
+	Hs
		789093 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		CASS4_HUMAN (4-829): 2.76e-79: 273: 22.64
+	Hs
		199501 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		EFS_HUMAN (7-264): 5.8e-20: 96.7: 26.34
+	Hs
		655289 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		BCAR1_HUMAN (1-832): 3e-84: 289: 33.44
+	Rn
		1144371 P85A_RAT (241-376): 8.21e-22: 99.1: 19.57		BCAR1_RAT (4-832): 1.74e-83: 289: 33.30
+	Rn
		1144044 FYN_RAT (7-173): 7.13e-21: 96: 15.39		BCAR1_RAT (4-832): 1.74e-83: 289: 33.30
+	Hs
		412110 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		BCAR1_HUMAN (1-832): 3e-84: 289: 33.44
+	Mm
		763397 FYN_MOUSE (7-173): 7.13e-21: 96: 15.39		BCAR1_MOUSE (1-832): 1.75e-82: 284: 32.86
+	Hs
		199489 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		EFS_HUMAN (7-264): 5.8e-20: 96.7: 26.34
+	Hs
		203208 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		SYNJ1_HUMAN (52-433): 1.04e-12: 74.4: 10.17
+	Hs
		91474 E7ERP6_HUMAN (1-76): 3.94e-36: 128: 78.95		EFS_HUMAN (7-264): 5.8e-20: 96.7: 26.34
+	Hs
		3145 A0A0S2Z4E4_HUMAN (1-181): 3.34e-26: 107: 74.87		EFS_HUMAN (7-264): 5.8e-20: 96.7: 26.34
+	Hs
		199493 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		EFS_HUMAN (7-264): 5.8e-20: 96.7: 26.34
+	Hs
		199505 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		EFS_HUMAN (7-264): 5.8e-20: 96.7: 26.34
+	Hs
		199497 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		EFS_HUMAN (7-264): 5.8e-20: 96.7: 26.34
+	Rn
		192744 SRBS2_RAT (3-162): 4.86e-25: 109: 28.05		SYNJ1_RAT (157-652): 2.37e-11: 69.8: 11.51
+	Hs
		203192 SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26		SYNJ1_HUMAN (52-433): 1.04e-12: 74.4: 10.17
+	Hs
		655439 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		SH3K1_HUMAN (8-74): 1.37e-11: 70.1: 31.34