Protein: SEN1
Helicase SEN1 (EC 3.6.4.-) (tRNA-splicing endonuclease positive effector)

Gene: SEN1
Organism: Saccharomyces cerevisiae S288C
Interactions: 204
UniProt ID: Q00416

Gene Ontology (top 5):
GO:0001147 - transcription termination site sequence-specific DNA binding
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

402081

RPB1
DNA-directed RNA polymerase II subunit RPB1

9

5

Small-scale

0.752

High

808771

NAB3
Nuclear polyadenylated RNA-binding protein 3

6

1

Small-scale

0.735

High

743267

PP12
Serine/threonine-protein phosphatase PP1-2

5

4

Small-scale

0.727

High

921603

NRD1
Protein NRD1

11

0

Small-scale

0.726

High

594511

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

2

Small-scale

0.676

High

454660

RAD2
DNA repair protein RAD2

3

3

Small-scale

0.670

High

1025163

RNT1
Ribonuclease 3

3

3

Small-scale

0.670

High

364691

CDK1
Cyclin-dependent kinase 1

2

2

Small-scale

0.639

High

694617

SPT5
Transcription elongation factor SPT5

3

3

Small-scale

0.633

High

757514

NCBP1
Nuclear cap-binding protein complex subunit 1

2

2

High-throughput

0.621

High

403619

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

12

Small-scale

0.601

High

798611

PAF1
RNA polymerase II-associated protein 1

2

1

Small-scale

0.588

High

470572

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

3

Small-scale

0.584

High

647184

RPC2
DNA-directed RNA polymerase III subunit RPC2

2

3

Small-scale

0.584

High

735111

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

1

Small-scale

0.584

High

826745

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.584

High

1025159

CTF4
DNA polymerase alpha-binding protein

2

9

Small-scale

0.584

High

1025198

NCBP2
Nuclear cap-binding protein subunit 2

2

13

High-throughput

0.584

High

432670

RL7A
Large ribosomal subunit protein uL30A

2

1

High-throughput

0.571

High

644970

RPA2
DNA-directed RNA polymerase I subunit RPA135

2

3

Small-scale

0.571

High

924987

APJ1
J domain-containing protein APJ1

2

5

High-throughput

0.571

High

632105

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

Small-scale

0.559

High

677695

MRC1
Mediator of replication checkpoint protein 1

2

0

Small-scale

0.559

High

524854

HSP71
Heat shock protein SSA1

2

6

High-throughput

0.552

High

1025158

RPA49
DNA-directed RNA polymerase I subunit RPA49

2

0

Small-scale

0.547

High

394822

EF1A
Elongation factor 1-alpha

1

4

High-throughput

0.536

High

448402

RAD1
DNA repair protein RAD1

1

1

High-throughput

0.536

High

574729

KSS1
Mitogen-activated protein kinase KSS1

1

1

High-throughput

0.536

High

692606

NSR1
Nuclear localization sequence-binding protein

1

16

Small-scale

0.536

High

780159

SDS22
Protein phosphatase 1 regulatory subunit SDS22

1

1

Small-scale

0.536

High

885058

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.536

High

1025201

YRA1
RNA annealing protein YRA1

1

8

Small-scale

0.536

High

1025175

POB3
FACT complex subunit POB3

2

3

Small-scale

0.533

High

694236

BUD14
Bud site selection protein 14

1

0

High-throughput

0.518

High

744911

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

0

High-throughput

0.518

High

847815

SMD3
Small nuclear ribonucleoprotein Sm D3

1

5

High-throughput

0.508

High

865276

LSM8
LSM2-LSM8 complex subunit LSM8

1

11

High-throughput

0.508

High

1025162

NUP49
Nucleoporin NUP49/NSP49

1

2

Small-scale

0.508

High

666523

DBP2
ATP-dependent RNA helicase DBP2

1

3

Small-scale

0.501

High

734296

PYC2
Pyruvate carboxylase 2

1

0

Small-scale

0.486

High

801790

KPR3
Ribose-phosphate pyrophosphokinase 3

1

0

Small-scale

0.486

High

1025161

GCR2
Glycolytic genes transcriptional activator GCR2

1

0

Small-scale

0.486

High

1025184

YP148
Uncharacterized protein YPR148C

1

0

Small-scale

0.486

High

557758

SRS2
ATP-dependent DNA helicase SRS2

1

2

Small-scale

0.481

High

732075

SYKM
Lysine--tRNA ligase, mitochondrial

1

1

Small-scale

0.481

High

735656

SMY1
Kinesin-related protein SMY1

1

8

High-throughput

0.481

High

777097

BDF1
Bromodomain-containing factor 1

1

9

High-throughput

0.481

High

402237

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

5

Small-scale

0.479

High

433272

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.479

High

459143

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

2

High-throughput

0.479

High

513744

RL2A
Large ribosomal subunit protein uL2A

1

1

High-throughput

0.479

High

534295

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

5

Small-scale

0.479

High

561325

DPOLA
DNA polymerase alpha catalytic subunit A

1

2

Small-scale

0.479

High

570111

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

632199

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.479

High

632281

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.479

High

642068

DPOE
DNA polymerase epsilon catalytic subunit A

1

2

Small-scale

0.479

High

645080

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.479

High

661185

SPT6
Transcription elongation factor SPT6

1

1

High-throughput

0.479

High

664461

MCM3
DNA replication licensing factor MCM3

1

3

Small-scale

0.479

High

672931

RRP43
Exosome complex component RRP43

1

1

High-throughput

0.479

High

689104

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.479

High

699967

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

2

High-throughput

0.479

High

700034

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

2

High-throughput

0.479

High

713292

MCM5
Minichromosome maintenance protein 5

1

3

Small-scale

0.479

High

721404

MCM4
DNA replication licensing factor MCM4

1

3

Small-scale

0.479

High

748146

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

1

Small-scale

0.479

High

757342

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

3

High-throughput

0.479

High

776306

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

3

Small-scale

0.479

High

781689

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

1

Small-scale

0.479

High

806943

RPB11
DNA-directed RNA polymerase II subunit RPB11

1

2

High-throughput

0.479

High

814739

EXO1
Exodeoxyribonuclease 1

1

5

High-throughput

0.479

High

826049

ULP2
Ubiquitin-like-specific protease 2

1

3

High-throughput

0.479

High

858240

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

1

High-throughput

0.479

High

917050

MCM6
DNA replication licensing factor MCM6

1

2

Small-scale

0.479

High

918321

RL26B
Large ribosomal subunit protein uL24B

1

4

High-throughput

0.479

High

921092

PRS10
26S proteasome subunit RPT4

1

2

High-throughput

0.479

High

925184

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.479

High

1025165

XRN2
5'-3' exoribonuclease 2

1

7

High-throughput

0.479

High

1025171

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

1025173

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

2

Small-scale

0.479

High

1025179

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

1025188

VAM6
Vacuolar morphogenesis protein 6

1

3

High-throughput

0.479

High

1025196

SGO1
Shugoshin

1

2

High-throughput

0.479

High

1025199

RRP6
Exosome complex exonuclease RRP6

1

6

High-throughput

0.479

High

1025200

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

999586

HSK3
DASH complex subunit HSK3

1

0

High-throughput

0.460

High

1025172

ECM11
Protein ECM11

1

0

High-throughput

0.460

High

609199

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

0

Small-scale

0.458

High

632364

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

665196

DPB2
DNA polymerase epsilon subunit B

1

0

Small-scale

0.458

High

674425

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

Small-scale

0.458

High

745839

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

748303

SPT4
Transcription elongation factor SPT4

1

0

High-throughput

0.458

High

805834

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.458

High

823723

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

864920

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

Small-scale

0.458

High

1025167

SLD5
DNA replication complex GINS protein SLD5

1

0

Small-scale

0.458

High

1025176

CSM3
Chromosome segregation in meiosis protein 3

1

0

Small-scale

0.458

High

1025183

IWS1
Transcription factor SPN1

1

0

High-throughput

0.458

High

1025189

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.458

High

1025193

CDC45
Cell division control protein 45

1

0

Small-scale

0.458

High

1025204

PSF1
DNA replication complex GINS protein PSF1

1

0

Small-scale

0.458

High

849685

RGD2
Rho-GTPase-activating protein RGD2

1

1

High-throughput

0.457

High

381597

H2B2
Histone H2B.2

1

1

Small-scale

0.445

High

382279

H4
Histone H4

1

4

Small-scale

0.445

High

419837

H2A2
Histone H2A.2

1

3

Small-scale

0.445

High

427404

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.445

High

444595

DED1
ATP-dependent RNA helicase DED1

1

3

Small-scale

0.445

High

518105

SSBP1
Single-stranded nucleic acid-binding protein

1

14

Small-scale

0.445

High

527433

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

545913

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.445

High

547819

NHP6A
Non-histone chromosomal protein 6A

1

7

Small-scale

0.445

High

585344

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

Small-scale

0.445

High

622998

CSK22
Casein kinase II subunit alpha'

1

2

Small-scale

0.445

High

632584

DBP3
ATP-dependent RNA helicase DBP3

1

4

Small-scale

0.445

High

632718

DBP4
ATP-dependent RNA helicase HCA4

1

9

Small-scale

0.445

High

637261

PWP1
Periodic tryptophan protein 1

1

11

Small-scale

0.445

High

645502

XRN1
5'-3' exoribonuclease 1

1

7

Small-scale

0.445

High

671017

SIS1
Protein SIS1

1

4

High-throughput

0.445

High

676260

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

676760

GBP2
Serine/arginine

1

18

Small-scale

0.445

High

677524

KRR1
KRR1 small subunit processome component

1

2

Small-scale

0.445

High

687072

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

5

Small-scale

0.445

High

700276

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

1

Small-scale

0.445

High

727249

HS104
Heat shock protein 104

1

1

High-throughput

0.445

High

737681

HIR2
Protein HIR2

1

8

Small-scale

0.445

High

738244

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

3

Small-scale

0.445

High

742183

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

750128

MRT4
Ribosome assembly factor MRT4

1

1

Small-scale

0.445

High

751460

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

Small-scale

0.445

High

751981

LHP1
La protein homolog

1

8

Small-scale

0.445

High

781642

DBP7
ATP-dependent RNA helicase DBP7

1

10

Small-scale

0.445

High

791089

NOP4
Nucleolar protein 4

1

13

Small-scale

0.445

High

801729

SRP68
Signal recognition particle subunit SRP68

1

1

Small-scale

0.445

High

801762

SRP72
Signal recognition particle subunit SRP72

1

1

Small-scale

0.445

High

802763

RRP3
ATP-dependent rRNA helicase RRP3

1

7

Small-scale

0.445

High

804376

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

807122

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

3

Small-scale

0.445

High

810874

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.445

High

811015

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.445

High

816536

SNU13
13 kDa ribonucleoprotein-associated protein

1

3

Small-scale

0.445

High

817143

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

4

Small-scale

0.445

High

819512

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

830161

NOP2
25S rRNA

1

1

Small-scale

0.445

High

865955

DPH4
Diphthamide biosynthesis protein 4

1

2

High-throughput

0.445

High

917453

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

Small-scale

0.445

High

917672

LSG1
Large subunit GTPase 1

1

1

Small-scale

0.445

High

923100

BRE5
UBP3-associated protein BRE5

1

6

Small-scale

0.445

High

924045

JJJ1
J protein JJJ1

1

3

High-throughput

0.445

High

924311

NOP13
Nucleolar protein 13

1

10

Small-scale

0.445

High

1025160

NOP3
Serine/arginine

1

20

Small-scale

0.445

High

1025166

IMA1
Importin subunit alpha

1

2

Small-scale

0.445

High

1025168

HAS1
ATP-dependent RNA helicase HAS1

1

11

Small-scale

0.445

High

1025170

HMO1
High mobility group protein 1

1

6

Small-scale

0.445

High

1025174

PUF6
Pumilio homology domain family member 6

1

5

Small-scale

0.445

High

1025177

RRP5
rRNA biogenesis protein RRP5

1

2

Small-scale

0.445

High

1025180

FKBP4
FK506-binding protein 4

1

3

Small-scale

0.445

High

1025182

LSM6
LSM complex subunit LSM6

1

2

Small-scale

0.445

High

1025187

YL419
Putative ATP-dependent RNA helicase YLR419W

1

7

Small-scale

0.445

High

1025190

NOP6
Nucleolar protein 6

1

1

Small-scale

0.445

High

1025194

NOP12
Nucleolar protein 12

1

14

Small-scale

0.445

High

1025195

BRX1
Ribosome biogenesis protein BRX1

1

5

Small-scale

0.445

High

1025197

RRS1
Regulator of ribosome biosynthesis

1

2

Small-scale

0.445

High

1025203

NOP56
Nucleolar protein 56

1

2

Small-scale

0.445

High

1025205

NOP58
Nucleolar protein 58

1

2

Small-scale

0.445

High

1025209

MEX67
mRNA export factor MEX67

1

4

Small-scale

0.445

High

748502

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

1018146

RL34A
Large ribosomal subunit protein eL34A

1

2

High-throughput

0.437

High

1025169

ESC1
Silent chromatin protein ESC1

1

2

High-throughput

0.437

High

154331

MBF1
Multiprotein-bridging factor 1

1

0

Small-scale

0.426

High

393175

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.426

High

557624

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

0

Small-scale

0.426

High

677954

YCQ6
Uncharacterized protein YCR016W

1

0

Small-scale

0.426

High

780304

EBP2
rRNA-processing protein EBP2

1

0

Small-scale

0.426

High

782411

RPF2
Ribosome biogenesis protein RPF2

1

0

Small-scale

0.426

High

800266

LEO1
RNA polymerase-associated protein LEO1

1

0

Small-scale

0.426

High

807912

BFR1
Nuclear segregation protein BFR1

1

0

Small-scale

0.426

High

809391

STM1
Suppressor protein STM1

1

0

Small-scale

0.426

High

814366

NOC2
Nucleolar complex protein 2

1

0

Small-scale

0.426

High

836176

GLC8
Protein GLC8

1

0

Small-scale

0.426

High

843258

KRI1
Protein KRI1

1

0

Small-scale

0.426

High

850004

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

0

Small-scale

0.426

High

864943

NOP9
Nucleolar protein 9

1

0

Small-scale

0.426

High

865039

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.426

High

871550

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.426

High

912430

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

924477

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

1018313

CTR9
RNA polymerase-associated protein CTR9

1

0

Small-scale

0.426

High

1025178

IMB1
Importin subunit beta-1

1

0

Small-scale

0.426

High

1025181

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

Small-scale

0.426

High

1025186

CDC73
Cell division control protein 73

1

0

Small-scale

0.426

High

1025191

NOC3
Nucleolar complex-associated protein 3

1

0

Small-scale

0.426

High

1025192

CMS1
Protein CMS1

1

0

Small-scale

0.426

High

1025206

RQC2
Ribosome quality control complex subunit 2

1

0

Small-scale

0.426

High

1025207

RRP12
Ribosomal RNA-processing protein 12

1

0

Small-scale

0.426

High

1025208

NOP10
H/ACA ribonucleoprotein complex subunit NOP10

1

0

Small-scale

0.426

High

1025185

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

4

High-throughput

0.407

High

739722

SPT16
FACT complex subunit SPT16

2

0

Small-scale

0.298

High

1025164

SLU7
Pre-mRNA-splicing factor SLU7

1

0

Small-scale

0.251

Low

1025202

GDIR
Rho GDP-dissociation inhibitor

1

0

High-throughput

0.251

Low

795151

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

720932

SEC1
Protein transport protein SEC1

1

0

Small-scale

0.232

Low

918083

JAC1
J-type co-chaperone JAC1, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025