HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0010976 - positive regulation of neuron projection development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 839
+	Hs
		209063 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Rn
		71362 B2RZ33_RAT (1-377): 8.61e-99: 300: 99.20		NTRK2_RAT (6-839): 0: 557: 52.88
+	Hs
		557707 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Hs
		209065 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Hs
		384213 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		507832 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		208983 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		557606 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		208993 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		434130 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		384434 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		208976 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		507897 ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		557671 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Hs
		557661 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		435526 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		209040 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Hs
		557826 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03
+	Rn
		88904 D4A3M8_RAT (1-376): 3.92e-90: 277: 66.93		INSR_RAT (513-824): 3.31e-62: 230: 38.80
+	Hs
		788974 TEC_HUMAN (27-377): 4.7e-38: 146: 17.63		FRK_HUMAN (533-814): 5.68e-57: 205: 37.23