HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: DOCK3 (Q8IZD9)
Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP)
Gene: DOCK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_2, SH3_1~SH3_2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 2030
+	Hs
		655417 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		DOCK3_HUMAN (1-2030): 0: 2302: 100.00
+	Hs
		412257 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		DOCK3_HUMAN (1-2030): 0: 2302: 100.00
+	Hs
		523056 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		DOCK3_HUMAN (1-2030): 0: 2302: 100.00
+	Hs
		924695 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		DOCK3_HUMAN (1-2030): 0: 2302: 100.00
+	Hs
		557689 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		DOCK1_HUMAN (2-1861): 0: 1887: 36.96
+	Hs
		209053 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		DOCK1_HUMAN (2-1861): 0: 1887: 36.96
+	Hs
		1078864 ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07		DOCK4_HUMAN (1-1996): 0: 2003: 54.58
+	Hs
		924698 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		DOCK4_HUMAN (1-1996): 0: 2003: 54.58
+	Mm
		1141146 GRB2_MOUSE (1-61): 1.55e-16: 79.4: 29.03		DOCK1_MOUSE (2-1855): 0: 1914: 37.08
+	Hs
		412190 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		DOCK1_HUMAN (2-1861): 0: 1887: 36.96
+	Hs
		522979 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		DOCK1_HUMAN (2-1861): 0: 1887: 36.96
+	Hs
		924565 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		DOCK1_HUMAN (2-1861): 0: 1887: 36.96
+	Hs
		924868 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		DOCK5_HUMAN (2-1851): 0: 1803: 34.82
+	Hs
		523071 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		DOCK8_HUMAN (723-957): 5.88e-31: 136: 8.98
+	Hs
		1056926 SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76		MDC1_HUMAN (1565-2030): 9.19e-14: 79.5: 11.16