HitPredict

Interactor 1: RPB3 (P16370)
DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (B44.5) (DNA-directed RNA polymerase II 45 kDa polypeptide)
Gene: RPB3

Interactor 2: RPB11 (P38902)
DNA-directed RNA polymerase II subunit RPB11 (RNA polymerase II subunit B11) (B13.6) (DNA-directed RNA polymerase II 13.6 kDa polypeptide)
Gene: RPB11

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.990

The method score is based on:

Property Details
Experiments 10784442, 10393904, 20637414, 11805826, 14749386, 15987790, 19394294, 37222571, 23418395, 23748379, 16554755, 16429126, 28585565, 29661922, 18467557, 34543624, 33888559, 34592154, 37968396, 21048197 and 2 others

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Identification Methods x-ray crystallography, two hybrid, pull down, tandem affinity purification, affinity chromatography technology, protein complementation assay, dihydrofolate reductase reconstruction
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains RNA_pol_L~RNA_pol_L_2
Common GO terms GO:0001055 - RNA polymerase II activity
GO:0001172 - RNA-templated transcription
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005665 - RNA polymerase II, core complex
and 5 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 318
Sc

1 120
+ Sc
+ Sp
+ Hs
+ Mm
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ At
+ Hs
+ At
+ Dm
+ Sp
+ Sc
+ Ss
+ Mj

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Last updated: 15 Jul 2024