Protein: SPTA1
Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin)

Gene: SPTA1
Organism: Homo sapiens
Interactions: 93
UniProt ID: P02549

Gene Ontology (top 5):
GO:0002260 - lymphocyte homeostasis
GO:0005200 - structural constituent of cytoskeleton
GO:0005509 - calcium ion binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

386429

SPTB1
Spectrin beta chain, erythrocytic

5

20

Small-scale

0.920

High

386434

ANK1
Ankyrin-1

2

20

Small-scale

0.778

High

362110

ABL1
Tyrosine-protein kinase ABL1

1

18

Small-scale

0.724

High

386461

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

20

Small-scale

0.692

High

386443

SHC1
SHC-transforming protein 1

1

14

High-throughput

0.691

High

386463

BTK
Tyrosine-protein kinase BTK

1

18

Small-scale

0.691

High

386474

ABI1
Abl interactor 1

1

13

Small-scale

0.653

High

386468

PLEC
Plectin

1

20

Small-scale

0.647

High

386423

P53
Cellular tumor antigen p53

1

7

High-throughput

0.618

High

386454

RD23B
UV excision repair protein RAD23 homolog B

1

15

Small-scale

0.618

High

386488

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

19

Small-scale

0.618

High

341720

K2C75
Keratin, type II cytoskeletal 75

2

6

High-throughput

0.606

High

386483

PKP2
Plakophilin-2

2

15

High-throughput

0.606

High

386492

EXOS5
Exosome complex component RRP46

2

1

High-throughput

0.606

High

187436

FANCA
Fanconi anemia group A protein

2

2

Small-scale

0.584

High

386422

SPTA1
Spectrin alpha chain, erythrocytic 1

1

19

Small-scale

0.575

High

386475

CC185
Coiled-coil domain-containing protein 185

2

11

High-throughput

0.553

High

386478

G45IP
Large ribosomal subunit protein mL64

2

1

High-throughput

0.553

High

386482

THIOM
Thioredoxin, mitochondrial

2

5

High-throughput

0.553

High

386493

TSH2
Teashirt homolog 2

2

7

High-throughput

0.553

High

386438

CBL
E3 ubiquitin-protein ligase CBL

1

13

High-throughput

0.536

High

386484

CP250
Centrosome-associated protein CEP250

1

20

High-throughput

0.536

High

386481

XPF
DNA repair endonuclease XPF

2

2

Small-scale

0.533

High

386427

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.515

High

160964

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

3

Small-scale

0.501

High

386440

1433T
14-3-3 protein theta

1

20

High-throughput

0.501

High

386446

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

1

Small-scale

0.501

High

386495

SL9A2
Sodium/hydrogen exchanger 2

1

1

Small-scale

0.501

High

386479

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

17

High-throughput

0.489

High

185137

FANCG
Fanconi anemia group G protein

1

1

Small-scale

0.479

High

373719

RASN
GTPase NRas

1

20

High-throughput

0.479

High

374324

RASH
GTPase HRas

1

20

High-throughput

0.479

High

375067

RASK
GTPase KRas

1

20

High-throughput

0.479

High

385344

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

12

Small-scale

0.479

High

386424

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.479

High

386426

RSSA
Small ribosomal subunit protein uS2

1

1

Small-scale

0.479

High

386428

MYBB
Myb-related protein B

1

9

Small-scale

0.479

High

386430

XRCC6
X-ray repair cross-complementing protein 6

1

2

Small-scale

0.479

High

386431

XRCC5
X-ray repair cross-complementing protein 5

1

2

Small-scale

0.479

High

386432

EZRI
Ezrin

1

20

Small-scale

0.479

High

386435

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

Small-scale

0.479

High

386441

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

Small-scale

0.479

High

386444

PML
Protein PML

1

14

Small-scale

0.479

High

386447

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

2

High-throughput

0.479

High

386449

EMD
Emerin

1

1

Small-scale

0.479

High

386453

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

7

Small-scale

0.479

High

386455

H2BFS
Histone H2B type F-S

1

13

High-throughput

0.479

High

386457

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

11

Small-scale

0.479

High

386459

ACTS
Actin, alpha skeletal muscle

1

20

Small-scale

0.479

High

386460

FANCC
Fanconi anemia group C protein

1

1

Small-scale

0.479

High

386464

RAD51
DNA repair protein RAD51 homolog 1

1

4

Small-scale

0.479

High

386466

CUL4A
Cullin-4A

1

13

High-throughput

0.479

High

386467

EEA1
Early endosome antigen 1

1

20

High-throughput

0.479

High

386470

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

1

Small-scale

0.479

High

386486

FACD2
Fanconi anemia group D2 protein

1

9

Small-scale

0.479

High

386489

GAN
Gigaxonin

1

7

High-throughput

0.479

High

386491

FANCF
Fanconi anemia group F protein

1

1

Small-scale

0.479

High

386497

E41L3
Band 4.1-like protein 3

1

20

Small-scale

0.479

High

386498

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

1

Small-scale

0.479

High

386499

NCOA3
Nuclear receptor coactivator 3

1

7

Small-scale

0.479

High

386469

H31T
Histone H3.1t

1

6

High-throughput

0.470

High

386465

Q0VAL7
C21orf58 protein

1

1

High-throughput

0.470

High

386439

XPA
DNA repair protein complementing XP-A cells

1

0

Small-scale

0.458

High

386445

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.458

High

386448

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

386477

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

386450

VASP
Vasodilator-stimulated phosphoprotein

1

14

Small-scale

0.457

High

386476

ENAH
Protein enabled homolog

1

20

Small-scale

0.457

High

386496

EVL
Ena/VASP-like protein

1

16

Small-scale

0.457

High

386473

CLC4G
C-type lectin domain family 4 member G

1

11

Small-scale

0.445

High

386456

CU058
Uncharacterized protein C21orf58

1

1

High-throughput

0.439

High

105074

APRIO
Alternative prion protein

1

10

High-throughput

0.437

High

220052

XRCC2
DNA repair protein XRCC2

1

4

Small-scale

0.437

High

352824

AGR2
Anterior gradient protein 2 homolog

1

7

High-throughput

0.437

High

386433

RFA2
Replication protein A 32 kDa subunit

1

13

Small-scale

0.437

High

386436

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

3

Small-scale

0.437

High

386437

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

Small-scale

0.437

High

386442

ERCC5
DNA excision repair protein ERCC-5

1

1

Small-scale

0.437

High

386451

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

5

Small-scale

0.437

High

386452

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

5

Small-scale

0.437

High

386458

H4
Histone H4

1

6

High-throughput

0.437

High

386462

ERCC6
DNA excision repair protein ERCC-6

1

7

Small-scale

0.437

High

386480

RAD50
DNA repair protein RAD50

1

20

Small-scale

0.437

High

386485

FANCJ
Fanconi anemia group J protein

1

1

Small-scale

0.437

High

386490

I20L2
Interferon-stimulated 20 kDa exonuclease-like 2

1

3

High-throughput

0.437

High

386494

VPS45
Vacuolar protein sorting-associated protein 45

1

4

High-throughput

0.437

High

71795

CMA1B
Ciliary microtubule associated protein 1B

2

0

High-throughput

0.316

High

166601

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

2

0

High-throughput

0.316

High

386471

ZN326
DBIRD complex subunit ZNF326

2

0

High-throughput

0.316

High

386487

DGC6L
Protein DGCR6L

2

0

High-throughput

0.316

High

386425

ERCC1
DNA excision repair protein ERCC-1

1

0

Small-scale

0.249

Low

386472

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025