HitPredict

Interactor 1: PRLR (P16471)
Prolactin receptor (PRL-R)
Gene: PRLR

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11713228
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 622 Hs			1 258
+	Hs
		146590 PRLR_HUMAN (1-622): 7.24e-167: 491: 100.00		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		147385 PRLR_HUMAN (1-622): 7.24e-167: 491: 100.00		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		560475 PRLR_HUMAN (1-622): 7.24e-167: 491: 100.00		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Mm
		645937 IL3RB_MOUSE (29-571): 1.45e-73: 255: 13.78		CISH_MOUSE (1-258): 3.74e-69: 215: 90.31
+	Hs
		540468 IL2RB_HUMAN (34-531): 2.89e-67: 231: 14.45		CISH_HUMAN (1-258): 2.61e-67: 210: 100.00
+	Rn
		70070 GHR_RAT (29-486): 4.19e-65: 227: 26.19		B1WBX9_RAT (1-258): 3.95e-68: 212: 90.31
+	Hs
		500974 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		CISH_HUMAN (1-258): 2.61e-67: 210: 100.00
+	Hs
		146586 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		147383 IL2RB_HUMAN (34-531): 2.89e-67: 231: 14.45		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		147382 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		181785 IL2RB_HUMAN (34-531): 2.89e-67: 231: 14.45		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Hs
		411578 IL2RB_HUMAN (34-531): 2.89e-67: 231: 14.45		LCK_HUMAN (44-196): 2.13e-39: 144: 17.39
+	Hs
		181779 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Mm
		562609 GHR_MOUSE (29-486): 5.85e-65: 227: 25.95		PTN11_MOUSE (77-222): 7.34e-26: 107: 19.46
+	Hs
		500960 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		985991 I22R1_HUMAN (9-538): 1.45e-63: 221: 15.72		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		540445 IL2RB_HUMAN (34-531): 2.89e-67: 231: 14.45		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Hs
		500948 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Hs
		129180 GHR_HUMAN (31-566): 5.33e-64: 224: 22.45		P85B_HUMAN (52-183): 6.6e-21: 93.4: 17.42
+	Hs
		129252 EPHA5_HUMAN (27-330): 3.07e-57: 210: 13.10		P85B_HUMAN (52-183): 6.6e-21: 93.4: 17.42