HitPredict

Interactor 1: SPTN1 (P16546)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain)
Gene: Sptan1

Interactor 2: HOME1 (Q9Z2Y3)
Homer protein homolog 1 (Homer-1) (VASP/Ena-related gene up-regulated during seizure and LTP 1) (Vesl-1)
Gene: Homer1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	28671696
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0030018 - Z disc GO:0044877 - protein-containing complex binding GO:0098794 - postsynapse and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2472 Mm			1 366
+	Mm
		82779 B9EKJ1_MOUSE (1-2472): 0: 692: 99.76		HOME1_MOUSE (1-366): 1.14e-85: 265: 100.00
+	Hs
		148786 SPTN1_HUMAN (1-2472): 0: 701: 98.42		CTRO_HUMAN (12-364): 1.36e-45: 169: 13.04
+	Hs
		1045471 SPTN1_HUMAN (1-2472): 0: 701: 98.42		MY18A_HUMAN (109-361): 6.07e-28: 117: 14.63
+	Hs
		1045559 SPTN1_HUMAN (1-2472): 0: 701: 98.42		EVL_HUMAN (1-167): 3.3e-22: 98.9: 20.69
+	Hs
		360628 SPTA1_HUMAN (1-2472): 6.26e-154: 536: 54.81		VASP_HUMAN (1-359): 1.49e-34: 132: 15.51
+	Hs
		360670 SPTA1_HUMAN (1-2472): 6.26e-154: 536: 54.81		EVL_HUMAN (1-167): 3.3e-22: 98.9: 20.69
+	Hs
		360652 SPTA1_HUMAN (1-2472): 6.26e-154: 536: 54.81		ENAH_HUMAN (1-235): 2.51e-19: 91.2: 19.67
+	Mm
		93541 SPTA1_MOUSE (1-2472): 5.73e-155: 539: 54.08		DESP_MOUSE (72-361): 3.8e-09: 60.4: 12.62
+	Mm
		1143729 SPTB2_MOUSE (1-1503): 2.83e-66: 252: 22.55		HOME1_MOUSE (1-366): 1.14e-85: 265: 100.00
+	Mm
		1148446 Q68FG2_MOUSE (1-1506): 1.1e-57: 224: 23.68		HOME1_MOUSE (1-366): 1.14e-85: 265: 100.00
+	Hs
		148690 SPTB2_HUMAN (1-1503): 9.12e-67: 254: 22.55		CTRO_HUMAN (12-364): 1.36e-45: 169: 13.04
+	Hs
		1205722 SPTN4_HUMAN (1-1166): 6.63e-39: 162: 20.43		HOME1_HUMAN (1-366): 4.29e-83: 258: 94.81
+	Hs
		148142 SPTN2_HUMAN (1-1506): 1.78e-58: 227: 23.09		CTRO_HUMAN (12-364): 1.36e-45: 169: 13.04
+	Hs
		963381 SPTB2_HUMAN (1-1503): 9.12e-67: 254: 22.55		MY18A_HUMAN (109-361): 6.07e-28: 117: 14.63
+	Hs
		164647 SPTN2_HUMAN (1-1506): 1.78e-58: 227: 23.09		MY18A_HUMAN (109-361): 6.07e-28: 117: 14.63
+	Hs
		149277 SPTN4_HUMAN (1-1166): 6.63e-39: 162: 20.43		CTRO_HUMAN (12-364): 1.36e-45: 169: 13.04
+	Hs
		840569 CP250_HUMAN (784-2448): 7.52e-50: 198: 10.05		VASP_HUMAN (1-359): 1.49e-34: 132: 15.51
+	Hs
		148841 PLEC_HUMAN (778-2427): 4.97e-24: 114: 9.67		CTRO_HUMAN (12-364): 1.36e-45: 169: 13.04
+	Hs
		974117 DYST_HUMAN (241-2373): 5.42e-33: 143: 9.50		MY18A_HUMAN (109-361): 6.07e-28: 117: 14.63
+	Hs
		1068617 PLEC_HUMAN (778-2427): 4.97e-24: 114: 9.67		MY18A_HUMAN (109-361): 6.07e-28: 117: 14.63