HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: LAMC2 (Q13753)
Laminin subunit gamma-2 (Cell-scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Epiligrin subunit gamma) (Kalinin subunit gamma) (Kalinin/nicein/epiligrin 100 kDa subunit) (Ladsin 140 kDa subunit) (Laminin B2t chain) (Laminin-5 subunit gamma) (Large adhesive scatter factor 140 kDa subunit) (Nicein subunit gamma)
Gene: LAMC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	31324722
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 1193
+	Hs
		563218 CFTR_HUMAN (1-1480): 0: 1106: 100.00		TENA_HUMAN (2-301): 6.54e-36: 151: 15.50
+	Hs
		563734 CFTR_HUMAN (1-1480): 0: 1106: 100.00		LAMB3_HUMAN (8-188): 2.07e-30: 132: 31.94
+	Hs
		556835 CFTR_HUMAN (1-1480): 0: 1106: 100.00		MYH1_HUMAN (640-1106): 3.37e-28: 125: 10.37
+	Hs
		563042 CFTR_HUMAN (1-1480): 0: 1106: 100.00		MYH8_HUMAN (635-1105): 7.35e-28: 124: 9.40
+	Hs
		564544 CFTR_HUMAN (1-1480): 0: 1106: 100.00		MYH2_HUMAN (617-1013): 9.28e-15: 81.9: 16.20
+	Hs
		563838 CFTR_HUMAN (1-1480): 0: 1106: 100.00		LAMA3_HUMAN (460-698): 7.92e-13: 75.7: 19.75
+	Hs
		183221 CFTR_HUMAN (1-1480): 0: 1106: 100.00		LAMA5_HUMAN (1-126): 8.17e-11: 69.2: 17.69
+	Dm
		451887 Q9VK56_DROME (765-1466): 4.35e-53: 207: 14.89		NOTCH_DROME (1-568): 1.5e-37: 156: 10.98