HitPredict

Interactor 1: HSP76 (P17066)
Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6)
Gene: HSPA6

Interactor 2: DNJB4 (Q9UDY4)
DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein)
Gene: DNAJB4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	21231916, 21988832
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006986 - response to unfolded protein GO:0051082 - unfolded protein binding GO:0051085 - chaperone cofactor-dependent protein refolding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 643 Hs			1 337
+	Hs
		714088 HS71L_HUMAN (1-643): 0: 960: 79.32		DNJB4_HUMAN (1-337): 9.06e-140: 400: 100.00
+	Hs
		279274 HSP76_HUMAN (1-643): 0: 970: 100.00		DNJB5_HUMAN (1-337): 1.41e-131: 380: 60.92
+	Hs
		279280 HS71L_HUMAN (1-643): 0: 960: 79.32		DNJB5_HUMAN (1-337): 1.41e-131: 380: 60.92
+	Hs
		504901 HSP7C_HUMAN (4-615): 0: 940: 79.25		DNJB4_HUMAN (1-337): 9.06e-140: 400: 100.00
+	Hs
		564008 HSP76_HUMAN (1-643): 0: 970: 100.00		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		636256 HS71L_HUMAN (1-643): 0: 960: 79.32		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		243284 HSP76_HUMAN (1-643): 0: 970: 100.00		DNJA2_HUMAN (2-336): 8.37e-120: 353: 31.46
+	Hs
		279272 HSP7C_HUMAN (4-615): 0: 940: 79.25		DNJB5_HUMAN (1-337): 1.41e-131: 380: 60.92
+	Hs
		564015 HSP76_HUMAN (1-643): 0: 970: 100.00		DNJA1_HUMAN (5-335): 9.73e-119: 349: 32.17
+	Hs
		564136 HSP76_HUMAN (1-643): 0: 970: 100.00		DNJA4_HUMAN (5-336): 1.32e-116: 344: 31.12
+	Hs
		243312 HS71L_HUMAN (1-643): 0: 960: 79.32		DNJA2_HUMAN (2-336): 8.37e-120: 353: 31.46
+	Hs
		681341 HS71L_HUMAN (1-643): 0: 960: 79.32		DNJA1_HUMAN (5-335): 9.73e-119: 349: 32.17
+	Hs
		503463 HSP7C_HUMAN (4-615): 0: 940: 79.25		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		243275 HSP7C_HUMAN (4-615): 0: 940: 79.25		DNJA2_HUMAN (2-336): 8.37e-120: 353: 31.46
+	Hs
		503527 HSP7C_HUMAN (4-615): 0: 940: 79.25		DNJA1_HUMAN (5-335): 9.73e-119: 349: 32.17
+	Hs
		564202 HSP76_HUMAN (1-643): 0: 970: 100.00		DJB11_HUMAN (2-334): 6.07e-99: 298: 31.34
+	Hs
		714087 HS71L_HUMAN (1-643): 0: 960: 79.32		DJB11_HUMAN (2-334): 6.07e-99: 298: 31.34
+	Hs
		504897 HSP7C_HUMAN (4-615): 0: 940: 79.25		DJB11_HUMAN (2-334): 6.07e-99: 298: 31.34
+	Hs
		564137 HSP76_HUMAN (1-643): 0: 970: 100.00		DNJB3_HUMAN (4-108): 5.57e-28: 108: 55.56
+	Hs
		504474 HSP7C_HUMAN (4-615): 0: 940: 79.25		DNJB3_HUMAN (4-108): 5.57e-28: 108: 55.56