Protein: KLH18
Kelch-like protein 18

Gene: KLH18, KLHL18
Organism: Homo sapiens
Interactions: 40
UniProt ID: O94889

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0016567 - protein ubiquitination
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051301 - cell division

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

320822

CUL3
Cullin-3

11

20

Small-scale

0.975

High

320821

CSN1
COP9 signalosome complex subunit 1

1

15

High-throughput

0.691

High

320836

CUL5
Cullin-5

1

20

High-throughput

0.691

High

320814

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

3

3

High-throughput

0.667

High

320828

CSN6
COP9 signalosome complex subunit 6

3

11

High-throughput

0.667

High

320830

NUDC3
NudC domain-containing protein 3

3

20

High-throughput

0.667

High

240342

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.665

High

320815

EF1G
Elongation factor 1-gamma

2

1

High-throughput

0.640

High

320811

BAG4
BAG family molecular chaperone regulator 4

2

3

High-throughput

0.628

High

320835

CSN5
COP9 signalosome complex subunit 5

2

12

High-throughput

0.628

High

320810

KLH18
Kelch-like protein 18

1

20

High-throughput

0.618

High

320816

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

2

Small-scale

0.618

High

320820

RBX1
E3 ubiquitin-protein ligase RBX1

2

7

Small-scale

0.611

High

320842

CSN3
COP9 signalosome complex subunit 3

2

17

High-throughput

0.611

High

320818

UBC12
NEDD8-conjugating enzyme Ubc12

3

14

High-throughput

0.609

High

320843

SGT1
Protein SGT1 homolog

3

5

High-throughput

0.609

High

320832

SMAP1
Stromal membrane-associated protein 1

2

1

High-throughput

0.601

High

169863

AURKA
Aurora kinase A

1

9

Small-scale

0.578

High

320812

CFAH
Complement factor H

2

2

High-throughput

0.567

High

320829

GPSM1
G-protein-signaling modulator 1

2

3

High-throughput

0.558

High

320813

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

251168

4EBP3
Eukaryotic translation initiation factor 4E-binding protein 3

1

1

High-throughput

0.536

High

320817

NEK4
Serine/threonine-protein kinase Nek4

1

5

High-throughput

0.536

High

320819

CSN2
COP9 signalosome complex subunit 2

1

19

High-throughput

0.536

High

320823

CASL
Enhancer of filamentation 1

1

2

High-throughput

0.536

High

320826

DCNL2
DCN1-like protein 2

1

9

High-throughput

0.536

High

320837

DCNL1
DCN1-like protein 1

1

9

High-throughput

0.536

High

320838

FUBP3
Far upstream element-binding protein 3

1

2

High-throughput

0.536

High

320833

IL1FA
Interleukin-1 family member 10

1

0

High-throughput

0.513

High

320834

CSN9
COP9 signalosome complex subunit 9

1

0

High-throughput

0.513

High

320841

RN181
E3 ubiquitin-protein ligase RNF181

1

0

High-throughput

0.513

High

139040

LAD1
Ladinin-1

1

2

High-throughput

0.489

High

320825

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

1

High-throughput

0.489

High

320839

CSN4
COP9 signalosome complex subunit 4

1

3

High-throughput

0.479

High

320831

CEP97
Centrosomal protein of 97 kDa

1

5

Small-scale

0.437

High

276805

VATG1
V-type proton ATPase subunit G 1

1

0

High-throughput

0.279

Low

320824

SPXN5
Sperm protein associated with the nucleus on the X chromosome N5

1

0

High-throughput

0.279

Low

320827

SHSA6
Protein shisa-6

1

0

High-throughput

0.279

Low

320840

RTF2
Replication termination factor 2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025