HitPredict

Interactor 1: PHO85 (P17157)
Cyclin-dependent protein kinase PHO85 (EC 2.7.11.22) (Negative regulator of the PHO system) (Serine/threonine-protein kinase PHO85)
Gene: PHO85

Interactor 2: KU80 (Q04437)
ATP-dependent DNA helicase II subunit 2 (EC 3.6.4.12) (ATP-dependent DNA helicase II subunit Ku80) (High affinity DNA-binding factor subunit 2) (Yeast Ku80)
Gene: YKU80

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	11805837, 33217428
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 305 Sc			1 629
+	Hs
		523528 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		XRCC6_HUMAN (2-602): 4.92e-131: 399: 15.06
+	Hs
		524796 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		XRCC5_HUMAN (2-607): 1.35e-124: 387: 14.99
+	Hs
		414706 CDK1_HUMAN (4-300): 1.59e-135: 387: 50.00		XRCC6_HUMAN (2-602): 4.92e-131: 399: 15.06
+	Sp
		293300 CDK1_SCHPO (4-301): 4.45e-128: 368: 48.85		KU70_SCHPO (1-614): 2.44e-133: 405: 16.05
+	Hs
		523605 CDK7_HUMAN (2-304): 5.47e-126: 365: 38.76		XRCC6_HUMAN (2-602): 4.92e-131: 399: 15.06
+	Hs
		524843 CDK7_HUMAN (2-304): 5.47e-126: 365: 38.76		XRCC5_HUMAN (2-607): 1.35e-124: 387: 14.99
+	Sp
		383475 CDK1_SCHPO (4-301): 4.45e-128: 368: 48.85		KU80_SCHPO (2-614): 6.42e-94: 305: 18.95