HitPredict

Interactor 1: INAR1 (P17181)
Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
Gene: IFNAR1

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	8626489
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 557 Hs			1 770
+	Hs
		566011 INAR1_HUMAN (1-557): 1.37e-149: 442: 100.00		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Mm
		708082 INAR1_MOUSE (18-548): 3.31e-113: 350: 48.97		STAT1_MOUSE (1-749): 0: 914: 51.32
+	Hs
		776851 I20RA_HUMAN (18-268): 6.6e-50: 182: 20.08		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		566017 INAR1_HUMAN (1-557): 1.37e-149: 442: 100.00		STAT2_HUMAN (1-728): 0: 786: 38.47
+	Mm
		786535 I10R1_MOUSE (5-242): 2.46e-44: 167: 17.97		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Mm
		546497 INGR1_MOUSE (2-344): 2.88e-34: 137: 14.09		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Mm
		786560 INLR1_MOUSE (209-427): 8.11e-26: 113: 17.54		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		770182 IL6RB_HUMAN (29-444): 2.89e-22: 103: 10.76		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776745 I22R1_HUMAN (233-490): 2.5e-11: 68.4: 14.87		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		566012 INAR1_HUMAN (1-557): 1.37e-149: 442: 100.00		STAT6_HUMAN (1-753): 0: 627: 24.10
+	Hs
		546441 INGR1_HUMAN (225-542): 2.4e-30: 126: 16.19		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Mm
		546502 INGR1_MOUSE (2-344): 2.88e-34: 137: 14.09		Q99K94_MOUSE (1-715): 0: 909: 53.62
+	Hs
		770183 IL6RB_HUMAN (29-444): 2.89e-22: 103: 10.76		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		786269 INAR2_HUMAN (37-202): 3.11e-09: 61.5: 16.57		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		819579 INAR2_HUMAN (37-202): 3.11e-09: 61.5: 16.57		STAT2_HUMAN (1-728): 0: 786: 38.47
+	Hs
		617014 PTPRD_HUMAN (99-452): 1.67e-23: 107: 14.68		Q9BXH2_HUMAN (702-752): 1.16e-16: 76.4: 98.04