HitPredict

Interactor 1: TAL1 (P17542)
T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5)
Gene: TAL1

Interactor 2: RBTN2 (P25791)
Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)
Gene: LMO2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.935

Property	Details
Experiments	8078932, 7568177, 7957052, 16407974, 35140242
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	HLH~LIM
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 331 Hs			1 158
+	Mm
		603898 TAL1_MOUSE (1-331): 1.7e-77: 242: 93.05		RBTN2_MOUSE (1-158): 3.35e-41: 137: 99.37
+	Hs
		568180 TAL1_HUMAN (1-331): 2.49e-79: 246: 100.00		RBTN1_HUMAN (11-150): 2.04e-38: 129: 52.86
+	Mm
		604035 TAL1_MOUSE (1-331): 1.7e-77: 242: 93.05		LMO3_MOUSE (30-156): 5.7e-39: 130: 58.27
+	Hs
		524537 LYL1_HUMAN (81-312): 1.23e-33: 127: 35.02		RBTN2_HUMAN (1-158): 4.5e-41: 136: 100.00
+	Hs
		524538 LYL1_HUMAN (81-312): 1.23e-33: 127: 35.02		RBTN1_HUMAN (11-150): 2.04e-38: 129: 52.86
+	Mm
		638617 ITF2_MOUSE (51-288): 4.18e-29: 119: 15.79		RBTN2_MOUSE (1-158): 3.35e-41: 137: 99.37
+	Hs
		210862 TCF21_HUMAN (144-294): 4.66e-30: 114: 29.22		LMO4_HUMAN (11-147): 3.1e-39: 132: 42.34
+	Hs
		638295 TAL2_HUMAN (186-257): 1.02e-26: 103: 72.22		RBTN2_HUMAN (1-158): 4.5e-41: 136: 100.00
+	Mm
		1143746 TAL2_MOUSE (186-257): 6.41e-28: 106: 70.83		LMO3_MOUSE (30-156): 5.7e-39: 130: 58.27
+	Mm
		1143747 TAL2_MOUSE (186-257): 6.41e-28: 106: 70.83		RBTN1_MOUSE (11-150): 3.96e-38: 128: 52.86
+	Hs
		638508 TAL2_HUMAN (186-257): 1.02e-26: 103: 72.22		RBTN1_HUMAN (11-150): 2.04e-38: 129: 52.86
+	Hs
		638265 HEN1_HUMAN (189-244): 4e-22: 91.8: 60.71		RBTN2_HUMAN (1-158): 4.5e-41: 136: 100.00
+	Dm
		114761 Q9VHG3_DROME (41-273): 3.94e-42: 149: 17.24		M9PD53_DROME (2-86): 7.78e-15: 72.3: 17.44
+	Dm
		1359764 Q9VHG3_DROME (41-273): 3.94e-42: 149: 17.24		Q9V472_DROME (94-155): 1.72e-09: 56.9: 22.58
+	Dm
		80870 DIMM_DROME (124-328): 5.49e-30: 119: 19.81		APTE_DROME (94-155): 2.27e-11: 62.3: 20.97
+	Dm
		1368265 Q9W4I4_DROME (189-244): 1.29e-21: 91.8: 57.14		Q9VJ00_DROME (2-86): 1.05e-14: 71.9: 17.44
+	Dm
		112565 Q9W4I4_DROME (189-244): 1.29e-21: 91.8: 57.14		M9NCY1_DROME (2-86): 7.53e-12: 63.8: 17.44