HitPredict

Interactor 1: SMUF2 (A2A5Z6)
E3 ubiquitin-protein ligase SMURF2 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: Smurf2

Interactor 2: SMAD1 (P70340)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (Dwarfin-A) (Dwf-A) (Mothers-against-DPP-related 1) (Mad-related protein 1) (mMad1) (SMAD family member 1) (SMAD 1) (Smad1)
Gene: SMAD1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	20956305, 23969857
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 748 Mm			1 465
+	Hs
		1078760 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD1_HUMAN (1-465): 0: 653: 99.14
+	Hs
		1305886 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD5_HUMAN (2-465): 0: 618: 89.25
+	Mm
		936618 SMUF1_MOUSE (1-748): 0: 753: 72.61		SMAD1_MOUSE (1-465): 0: 654: 100.00
+	Hs
		1078761 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD1_HUMAN (1-465): 0: 653: 99.14
+	Hs
		950287 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD3_HUMAN (3-465): 0: 554: 59.44
+	Xl
		945613 SMUF1_XENLA (1-748): 0: 745: 70.77		P79947_XENLA (1-465): 0: 642: 94.19
+	Hs
		1078667 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD2_HUMAN (3-465): 0: 537: 55.14
+	Hs
		1305888 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD5_HUMAN (2-465): 0: 618: 89.25
+	Hs
		950291 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD3_HUMAN (3-465): 0: 554: 59.44
+	Hs
		1078671 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD2_HUMAN (3-465): 0: 537: 55.14
+	Hs
		1035596 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD4_HUMAN (8-454): 1.16e-150: 441: 33.15
+	Mm
		1143948 ITCH_MOUSE (1-748): 0: 667: 32.34		SMAD2_MOUSE (3-465): 0: 539: 55.14
+	Hs
		1035600 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD4_HUMAN (8-454): 1.16e-150: 441: 33.15
+	Hs
		206976 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD6_HUMAN (36-443): 3.18e-93: 292: 25.61
+	Mm
		192368 SMUF1_MOUSE (1-748): 0: 753: 72.61		SMAD6_MOUSE (36-442): 9.61e-89: 280: 26.16
+	Hs
		206977 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD6_HUMAN (36-443): 3.18e-93: 292: 25.61
+	Hs
		167394 SMUF2_HUMAN (1-748): 0: 835: 99.20		SMAD7_HUMAN (30-131): 2.87e-25: 109: 32.46
+	Mm
		56823 SMUF2_MOUSE (1-748): 0: 837: 100.00		SMAD7_MOUSE (30-131): 1.02e-24: 107: 33.33
+	Mm
		192495 SMUF1_MOUSE (1-748): 0: 753: 72.61		SMAD7_MOUSE (30-131): 1.02e-24: 107: 33.33
+	Hs
		167395 SMUF1_HUMAN (1-748): 0: 741: 70.05		SMAD7_HUMAN (30-131): 2.87e-25: 109: 32.46