HitPredict

Interactor 1: KAPCA (P17612)
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Gene: PRKACA

Interactor 2: KAPCB (P22694)
cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)
Gene: PRKACB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.971

The method score is based on:

Property Details
Experiments 33957083, 35271311, 32707033, 30274258, 23455922, 28514442, 24981860, 33961781
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000287 - magnesium ion binding
GO:0001843 - neural tube closure
GO:0003091 - renal water homeostasis
GO:0004674 - protein serine/threonine kinase activity
GO:0004679 - AMP-activated protein kinase activity
and 18 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 351
Hs

1 351
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Mm
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+ Mm
+ Hs
+ Hs
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+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024