HitPredict

Interactor 1: KAPCA (P17612)
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Gene: PRKACA

Interactor 2: MYOME (Q5VU43)
Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein)
Gene: PDE4DIP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	29162697, 35271311, 32707033, 30274258, 23455922
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005813 - centrosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 351 Hs			1 2346
+	Hs
		610736 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		MYOME_HUMAN (1-2346): 0: 703: 100.00
+	Hs
		609676 KAPCG_HUMAN (1-351): 2.31e-162: 459: 82.91		MYOME_HUMAN (1-2346): 0: 703: 100.00
+	Mm
		933112 KAPCB_MOUSE (1-351): 5.81e-161: 455: 92.31		MYOME_MOUSE (1-2346): 2.71e-171: 585: 69.33
+	Hs
		610802 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		MYH4_HUMAN (1279-2334): 2.89e-32: 140: 9.95
+	Hs
		610795 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		MYH2_HUMAN (1264-2333): 5.78e-32: 139: 10.08
+	Hs
		528359 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		MYH6_HUMAN (1376-2333): 1.06e-22: 109: 8.98
+	Hs
		522538 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		MYH1_HUMAN (1591-2329): 2.23e-20: 101: 10.95
+	Hs
		568568 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		MYH10_HUMAN (1099-2077): 1.03e-18: 96.2: 11.20
+	Hs
		568772 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		CK5P2_HUMAN (1-1501): 2.27e-17: 91.6: 8.90
+	Hs
		610771 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		CK5P2_HUMAN (1-1501): 2.27e-17: 91.6: 8.90
+	Mm
		554901 KPCE_MOUSE (9-351): 4.22e-141: 419: 36.70		MYH6_MOUSE (1379-2333): 4.13e-28: 127: 9.32
+	Hs
		568567 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		MYH9_HUMAN (1753-2327): 1.1e-12: 76.2: 11.23
+	Hs
		568780 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		AKAP9_HUMAN (196-822): 2.21e-10: 68.9: 11.25
+	Hs
		610775 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		AKAP9_HUMAN (196-822): 2.21e-10: 68.9: 11.25
+	Hs
		609694 KAPCG_HUMAN (1-351): 2.31e-162: 459: 82.91		AKAP9_HUMAN (196-822): 2.21e-10: 68.9: 11.25
+	Hs
		681696 AKT1_HUMAN (7-347): 2.89e-149: 430: 38.79		MYH9_HUMAN (1753-2327): 1.1e-12: 76.2: 11.23
+	Hs
		551616 AKT1_HUMAN (7-347): 2.89e-149: 430: 38.79		DESP_HUMAN (6-681): 6.09e-10: 67.4: 20.72
+	Hs
		724784 KPCE_HUMAN (9-351): 6.36e-141: 418: 36.42		MYH9_HUMAN (1753-2327): 1.1e-12: 76.2: 11.23
+	Mm
		554927 KPCE_MOUSE (9-351): 4.22e-141: 419: 36.70		MYH7_MOUSE (2-357): 7.13e-10: 67: 8.82
+	Hs
		551672 KPCE_HUMAN (9-351): 6.36e-141: 418: 36.42		DESP_HUMAN (6-681): 6.09e-10: 67.4: 20.72