Protein: GYS1
Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1)

Gene: GYS1
Organism: Homo sapiens
Interactions: 134
UniProt ID: P13807

Gene Ontology (top 5):
GO:0004373 - alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
GO:0005536 - D-glucose binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005978 - glycogen biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

568616

GLYG
Glycogenin-1

6

8

Small-scale

0.957

High

192008

GLYG2
Glycogenin-2

4

8

High-throughput

0.911

High

568626

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

5

6

High-throughput

0.723

High

225525

AAKB2
5'-AMP-activated protein kinase subunit beta-2

4

3

High-throughput

0.697

High

568707

PPR3C
Protein phosphatase 1 regulatory subunit 3C

4

11

High-throughput

0.697

High

329507

STBD1
Starch-binding domain-containing protein 1

4

1

High-throughput

0.691

High

568615

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

3

6

High-throughput

0.667

High

568619

GSK3B
Glycogen synthase kinase-3 beta

4

3

Small-scale

0.667

High

568629

GLGB
1,4-alpha-glucan-branching enzyme

2

1

High-throughput

0.628

High

216875

KLF4
Krueppel-like factor 4

2

1

High-throughput

0.606

High

568620

MEOX1
Homeobox protein MOX-1

2

2

High-throughput

0.606

High

568664

KAISO
Transcriptional regulator Kaiso

2

1

High-throughput

0.606

High

568660

NHLC1
E3 ubiquitin-protein ligase NHLRC1

2

1

Small-scale

0.595

High

568639

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

0

High-throughput

0.585

High

568685

CSN5
COP9 signalosome complex subunit 5

2

0

High-throughput

0.585

High

250201

VINEX
Vinexin

2

0

High-throughput

0.580

High

568618

PCY1A
Choline-phosphate cytidylyltransferase A

2

0

High-throughput

0.580

High

568633

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

568649

BOREA
Borealin

2

0

High-throughput

0.580

High

568683

SNIP1
Smad nuclear-interacting protein 1

2

0

High-throughput

0.580

High

568697

KTBL1
KATNB1-like protein 1

2

0

High-throughput

0.580

High

568622

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

1

High-throughput

0.571

High

240634

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

568607

HXB6
Homeobox protein Hox-B6

2

1

High-throughput

0.553

High

568612

HXC8
Homeobox protein Hox-C8

2

2

High-throughput

0.553

High

568637

KLF1
Krueppel-like factor 1

2

2

High-throughput

0.553

High

568661

ZN620
Zinc finger protein 620

2

1

High-throughput

0.553

High

568704

ZN212
Zinc finger protein 212

2

1

High-throughput

0.553

High

568634

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.549

High

539512

PYGB
Glycogen phosphorylase, brain form

1

2

High-throughput

0.536

High

568627

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

6

High-throughput

0.536

High

568635

MK07
Mitogen-activated protein kinase 7

1

2

High-throughput

0.536

High

568648

AAK1
AP2-associated protein kinase 1

1

3

High-throughput

0.536

High

568698

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

6

High-throughput

0.536

High

568706

CE164
Centrosomal protein of 164 kDa

1

1

High-throughput

0.536

High

563106

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.528

High

568668

PPR3B
Protein phosphatase 1 regulatory subunit 3B

2

11

High-throughput

0.521

High

568711

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

3

High-throughput

0.515

High

539937

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.513

High

568623

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

0

High-throughput

0.513

High

568638

CUL1
Cullin-1

1

0

High-throughput

0.513

High

568643

STK38
Serine/threonine-protein kinase 38

1

0

High-throughput

0.513

High

568644

PP1R7
Protein phosphatase 1 regulatory subunit 7

1

0

High-throughput

0.513

High

568656

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

0

High-throughput

0.513

High

568674

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

0

High-throughput

0.513

High

568687

SGK3
Serine/threonine-protein kinase Sgk3

1

0

High-throughput

0.513

High

568688

GASP2
G-protein coupled receptor-associated sorting protein 2

1

0

High-throughput

0.513

High

568689

OTUD5
OTU domain-containing protein 5

1

0

High-throughput

0.513

High

568691

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.513

High

568699

SLK
STE20-like serine/threonine-protein kinase

1

0

High-throughput

0.513

High

568670

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

0

High-throughput

0.493

High

415137

AMYP
Pancreatic alpha-amylase

1

1

High-throughput

0.489

High

568647

PDK4
[Pyruvate dehydrogenase

1

1

High-throughput

0.489

High

568690

ZN514
Zinc finger protein 514

1

1

High-throughput

0.489

High

421419

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

131705

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

Small-scale

0.479

High

315072

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

568610

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

568624

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

6

High-throughput

0.479

High

568645

MK11
Mitogen-activated protein kinase 11

1

4

Small-scale

0.479

High

568646

MK14
Mitogen-activated protein kinase 14

1

4

Small-scale

0.479

High

568675

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

568695

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

6

High-throughput

0.479

High

568696

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

6

High-throughput

0.479

High

568700

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

568702

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

69353

WASH1
WASH complex subunit 1

1

0

High-throughput

0.460

High

172442

XPO1
Exportin-1

1

0

High-throughput

0.458

High

176934

CE290
Centrosomal protein of 290 kDa

1

0

High-throughput

0.458

High

324087

CE152
Centrosomal protein of 152 kDa

1

0

High-throughput

0.458

High

348047

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

0

High-throughput

0.458

High

403788

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

568609

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

High-throughput

0.458

High

568613

GRK5
G protein-coupled receptor kinase 5

1

0

High-throughput

0.458

High

568621

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

568628

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

Small-scale

0.458

High

568632

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

568641

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

568642

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

568655

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.458

High

568662

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

568666

LBN
Limbin

1

0

High-throughput

0.458

High

568669

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.458

High

568676

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

568678

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

568684

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

327775

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

6

High-throughput

0.445

High

568630

BTK
Tyrosine-protein kinase BTK

1

1

High-throughput

0.445

High

568693

PASK
PAS domain-containing serine/threonine-protein kinase

1

1

Small-scale

0.445

High

568680

ZFP41
Zinc finger protein 41 homolog

1

1

High-throughput

0.437

High

568682

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.437

High

50485

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.426

High

213056

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

568640

BECN1
Beclin-1

1

0

High-throughput

0.426

High

568653

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.426

High

568657

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

568694

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

568703

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.426

High

568708

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

568709

SHLB1
Endophilin-B1

1

0

High-throughput

0.426

High

429222

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

517205

AMY1B
Alpha-amylase 1B

1

1

High-throughput

0.407

High

568673

IHO1
Interactor of HORMAD1 protein 1

3

0

High-throughput

0.352

High

209947

CRX
Cone-rod homeobox protein

2

0

High-throughput

0.316

High

568608

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

2

0

High-throughput

0.316

High

568631

TLE5
TLE family member 5

2

0

High-throughput

0.316

High

568650

ZN326
DBIRD complex subunit ZNF326

2

0

High-throughput

0.316

High

568651

EFHC2
EF-hand domain-containing family member C2

2

0

High-throughput

0.316

High

568652

RBM48
RNA-binding protein 48

2

0

High-throughput

0.316

High

568654

CLVS2
Clavesin-2

2

0

High-throughput

0.316

High

568658

ZN774
Zinc finger protein 774

2

0

High-throughput

0.316

High

568659

ZN474
Zinc finger protein 474

2

0

High-throughput

0.316

High

568663

AP2D
Transcription factor AP-2-delta

2

0

High-throughput

0.316

High

568667

F228A
Protein FAM228A

2

0

High-throughput

0.316

High

568679

BEND7
BEN domain-containing protein 7

2

0

High-throughput

0.316

High

568686

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

2

0

High-throughput

0.316

High

568692

PNMA5
Paraneoplastic antigen-like protein 5

2

0

High-throughput

0.316

High

568701

ZN552
Zinc finger protein 552

2

0

High-throughput

0.316

High

568705

PLAL2
Zinc finger protein PLAGL2

2

0

High-throughput

0.316

High

187586

SOX12
Transcription factor SOX-12

1

0

High-throughput

0.279

Low

568665

TLK2
Serine/threonine-protein kinase tousled-like 2

1

0

High-throughput

0.279

Low

568625

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.261

Low

568677

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

411285

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

473759

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.249

Low

568606

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

568611

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

568614

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

568617

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

568636

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

568672

TM192
Transmembrane protein 192

1

0

High-throughput

0.249

Low

568671

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.232

Low

568681

SYT2
Synaptotagmin-2

1

0

High-throughput

0.232

Low

568710

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025