HitPredict

Interactor 1: MED14 (A2ABV5)
Mediator of RNA polymerase II transcription subunit 14 (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170)
Gene: MED14

Interactor 2: PPARG (P37238)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
Gene: PPARG

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20194623
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1459 Mm			1 505
+	Hs
		225353 MED14_HUMAN (1-1459): 0: 1772: 96.03		PPARG_HUMAN (1-505): 1.01e-174: 503: 96.04
+	Hs
		225328 MED14_HUMAN (1-1459): 0: 1772: 96.03		ESR1_HUMAN (38-501): 2.35e-107: 333: 19.26
+	Hs
		225330 MED14_HUMAN (1-1459): 0: 1772: 96.03		GCR_HUMAN (2-503): 1.51e-101: 323: 18.47
+	Hs
		225354 MED14_HUMAN (1-1459): 0: 1772: 96.03		HNF4A_HUMAN (89-501): 7.67e-102: 315: 20.52
+	Hs
		225340 MED14_HUMAN (1-1459): 0: 1772: 96.03		VDR_HUMAN (120-504): 2.97e-95: 297: 24.23
+	Dm
		709214 MED14_DROME (47-1453): 0: 1366: 36.96		ECR_DROME (128-501): 1.98e-98: 317: 26.73
+	Hs
		740556 KMT2C_HUMAN (964-1302): 3.75e-11: 70.6: 13.60		PPARG_HUMAN (1-505): 1.01e-174: 503: 96.04
+	Hs
		740566 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		PPARG_HUMAN (1-505): 1.01e-174: 503: 96.04
+	Hs
		377716 SC31B_HUMAN (959-1211): 4.59e-27: 122: 21.02		GCR_HUMAN (2-503): 1.51e-101: 323: 18.47
+	Hs
		782707 CABIN_HUMAN (979-1234): 7.34e-25: 115: 16.91		HNF4A_HUMAN (89-501): 7.67e-102: 315: 20.52
+	Hs
		975458 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		PPARD_HUMAN (102-505): 2.25e-119: 359: 59.75
+	Hs
		587190 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		RXRA_HUMAN (3-502): 4.1e-114: 346: 22.86
+	Hs
		370040 KMT2C_HUMAN (964-1302): 3.75e-11: 70.6: 13.60		ESR1_HUMAN (38-501): 2.35e-107: 333: 19.26
+	Hs
		370136 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		ESR1_HUMAN (38-501): 2.35e-107: 333: 19.26
+	Hs
		488001 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		RARA_HUMAN (32-503): 2.97e-106: 326: 25.90
+	Hs
		377554 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		GCR_HUMAN (2-503): 1.51e-101: 323: 18.47
+	Hs
		782578 SRCAP_HUMAN (920-1230): 9.14e-12: 72.6: 11.73		HNF4A_HUMAN (89-501): 7.67e-102: 315: 20.52
+	Hs
		782595 KMT2C_HUMAN (964-1302): 3.75e-11: 70.6: 13.60		HNF4A_HUMAN (89-501): 7.67e-102: 315: 20.52
+	Hs
		782610 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		HNF4A_HUMAN (89-501): 7.67e-102: 315: 20.52
+	Hs
		509968 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		VDR_HUMAN (120-504): 2.97e-95: 297: 24.23