HitPredict

Interactor 1: HLAG (P17693)
HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G)]
Gene: HLA-G

Interactor 2: LIRB2 (Q8N423)
Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)
Gene: LILRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.962

The method score is based on:

Property Details
Experiments 17056715, 24018270, 28348268, 22802125, 12853576, 16455647, 24899623
Identification Methods surface plasmon resonance, affinity technology, comigration in non denaturing gel electrophoresis, molecular sieving, affinity chromatography technology, fluorescence-activated cell sorting
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains C1-set~ig, C1-set~Ig_2, MHC_I~ig
Common GO terms GO:0002645 - positive regulation of tolerance induction
GO:0002666 - positive regulation of T cell tolerance induction
GO:0002767 - immune response-inhibiting cell surface receptor signaling pathway
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
and 6 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024