HitPredict

Interactor 1: MED14 (A2ABV5)
Mediator of RNA polymerase II transcription subunit 14 (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170)
Gene: MED14

Interactor 2: ERR2 (Q61539)
Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
Gene: Esrrb

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	20362541
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0035019 - somatic stem cell population maintenance GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1459 Mm			1 433
+	Hs
		225328 MED14_HUMAN (1-1459): 0: 1772: 96.03		ESR1_HUMAN (10-432): 1.33e-111: 342: 33.05
+	Hs
		225354 MED14_HUMAN (1-1459): 0: 1772: 96.03		HNF4A_HUMAN (78-429): 2.37e-109: 332: 28.61
+	Hs
		225402 MED14_HUMAN (1-1459): 0: 1772: 96.03		ESR2_HUMAN (102-433): 1.13e-69: 231: 38.61
+	Hs
		225330 MED14_HUMAN (1-1459): 0: 1772: 96.03		GCR_HUMAN (99-352): 1.26e-45: 170: 37.98
+	Hs
		587190 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		RXRA_HUMAN (8-431): 1.52e-128: 381: 28.44
+	Hs
		782707 CABIN_HUMAN (979-1234): 7.34e-25: 115: 16.91		HNF4A_HUMAN (78-429): 2.37e-109: 332: 28.61
+	Hs
		370040 KMT2C_HUMAN (964-1302): 3.75e-11: 70.6: 13.60		ESR1_HUMAN (10-432): 1.33e-111: 342: 33.05
+	Hs
		370136 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		ESR1_HUMAN (10-432): 1.33e-111: 342: 33.05
+	Hs
		795602 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		NR4A2_HUMAN (32-429): 3.36e-110: 338: 27.38
+	Hs
		782578 SRCAP_HUMAN (920-1230): 9.14e-12: 72.6: 11.73		HNF4A_HUMAN (78-429): 2.37e-109: 332: 28.61
+	Hs
		488001 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		RARA_HUMAN (38-430): 2.72e-111: 336: 27.64
+	Hs
		782595 KMT2C_HUMAN (964-1302): 3.75e-11: 70.6: 13.60		HNF4A_HUMAN (78-429): 2.37e-109: 332: 28.61
+	Hs
		782610 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		HNF4A_HUMAN (78-429): 2.37e-109: 332: 28.61
+	Hs
		1270056 CABIN_HUMAN (979-1234): 7.34e-25: 115: 16.91		ESR2_HUMAN (102-433): 1.13e-69: 231: 38.61
+	Hs
		867111 SC24C_HUMAN (885-1209): 4.29e-15: 83: 15.82		ESR2_HUMAN (102-433): 1.13e-69: 231: 38.61
+	Hs
		1243831 KMT2C_HUMAN (964-1302): 3.75e-11: 70.6: 13.60		ESR2_HUMAN (102-433): 1.13e-69: 231: 38.61
+	Hs
		1270066 PCLO_HUMAN (892-1298): 1.23e-10: 68.7: 9.98		ESR2_HUMAN (102-433): 1.13e-69: 231: 38.61
+	Hs
		1269276 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		ESR2_HUMAN (102-433): 1.13e-69: 231: 38.61
+	Hs
		377716 SC31B_HUMAN (959-1211): 4.59e-27: 122: 21.02		GCR_HUMAN (99-352): 1.26e-45: 170: 37.98
+	Hs
		377554 CBP_HUMAN (989-1297): 3.53e-10: 67.2: 14.01		GCR_HUMAN (99-352): 1.26e-45: 170: 37.98