HitPredict

Interactor 1: DDX5 (P17844)
Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)
Gene: DDX5

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	20020773, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003730 - mRNA 3'-UTR binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck and 1 others more... GO:0048511 - rhythmic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 614 Hs			1 414
+	Mm
		1207264 Q8BTS0_MOUSE (1-614): 0: 617: 97.89		TADBP_MOUSE (1-414): 1.47e-79: 253: 96.14
+	Hs
		161959 DDX5_HUMAN (1-614): 0: 624: 100.00		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		571368 DDX5_HUMAN (1-614): 0: 624: 100.00		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		1025882 DDX17_HUMAN (30-612): 0: 534: 66.83		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Mm
		857351 Q8BTS0_MOUSE (1-614): 0: 617: 97.89		TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92
+	Hs
		134014 DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Mm
		857323 DDX17_MOUSE (30-612): 0: 536: 66.67		TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92
+	Hs
		1048159 DDX17_HUMAN (30-612): 0: 534: 66.83		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		134018 DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		133858 DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95