HitPredict

Interactor 1: DDX5 (P17844)
Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)
Gene: DDX5

Interactor 2: SMAD5 (Q99717)
Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5)
Gene: SMAD5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	18548003
Identification Methods	pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006357 - regulation of transcription by RNA polymerase II and 1 others more... GO:0030509 - BMP signaling pathway
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 614 Hs			1 465
+	Hs
		571470 DDX5_HUMAN (1-614): 0: 624: 100.00		SMAD1_HUMAN (3-465): 0: 637: 89.68
+	Mm
		936615 Q8BTS0_MOUSE (1-614): 0: 617: 97.89		SMAD1_MOUSE (3-465): 0: 638: 89.89
+	Hs
		571401 DDX5_HUMAN (1-614): 0: 624: 100.00		SMAD3_HUMAN (4-465): 0: 550: 58.97
+	Mm
		1207259 Q8BTS0_MOUSE (1-614): 0: 617: 97.89		SMAD3_MOUSE (4-465): 0: 550: 58.97
+	Mm
		1143947 Q8BTS0_MOUSE (1-614): 0: 617: 97.89		SMAD2_MOUSE (4-465): 0: 532: 55.60
+	Mm
		956548 Q8BTS0_MOUSE (1-614): 0: 617: 97.89		SMAD4_MOUSE (14-462): 4.6e-152: 445: 34.70
+	Hs
		133977 DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52		SMAD3_HUMAN (4-465): 0: 550: 58.97
+	Hs
		181693 DDX3Y_HUMAN (2-556): 1.95e-145: 438: 34.93		SMAD3_HUMAN (4-465): 0: 550: 58.97
+	Hs
		181701 DDX3Y_HUMAN (2-556): 1.95e-145: 438: 34.93		SMAD2_HUMAN (4-465): 0: 530: 55.60
+	Mm
		192488 Q8BTS0_MOUSE (1-614): 0: 617: 97.89		SMAD7_MOUSE (31-132): 3.3e-26: 112: 32.46