HitPredict

Interactor 1: LEG3 (P17931)
Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen)
Gene: LGALS3

Interactor 2: PTPRZ (P23471)
Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2)
Gene: PTPRZ1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 250 Hs			1 2315
+	Hs
		449194 LEG1_HUMAN (125-247): 3.18e-43: 144: 28.00		PTPRZ_HUMAN (1-2315): 0: 1711: 100.00
+	Hs
		572281 LEG3_HUMAN (1-250): 3.29e-96: 283: 100.00		PTPRG_HUMAN (28-665): 1.12e-131: 454: 27.26
+	Hs
		572351 LEG3_HUMAN (1-250): 3.29e-96: 283: 100.00		PTPRJ_HUMAN (1995-2289): 4.87e-102: 362: 27.33
+	Hs
		572363 LEG3_HUMAN (1-250): 3.29e-96: 283: 100.00		PTPRK_HUMAN (1998-2314): 2.28e-101: 362: 24.30
+	Hs
		572277 LEG3_HUMAN (1-250): 3.29e-96: 283: 100.00		PTPRA_HUMAN (2023-2314): 3.27e-103: 353: 26.33
+	Hs
		572368 LEG3_HUMAN (1-250): 3.29e-96: 283: 100.00		PTPRO_HUMAN (1998-2280): 1.35e-97: 347: 28.03
+	Hs
		449193 LEG1_HUMAN (125-247): 3.18e-43: 144: 28.00		PTPRG_HUMAN (28-665): 1.12e-131: 454: 27.26
+	Hs
		119173 LEG9_HUMAN (108-249): 3.89e-40: 143: 37.67		PTPRG_HUMAN (28-665): 1.12e-131: 454: 27.26
+	Hs
		449191 LEG1_HUMAN (125-247): 3.18e-43: 144: 28.00		PTPRB_HUMAN (1801-2310): 3.65e-109: 391: 23.82
+	Hs
		814938 LEG7_HUMAN (115-247): 3.1e-45: 149: 35.04		PTPRJ_HUMAN (1995-2289): 4.87e-102: 362: 27.33
+	Hs
		814954 LEG7_HUMAN (115-247): 3.1e-45: 149: 35.04		PTPRK_HUMAN (1998-2314): 2.28e-101: 362: 24.30
+	Hs
		449248 LEG1_HUMAN (125-247): 3.18e-43: 144: 28.00		PTPRJ_HUMAN (1995-2289): 4.87e-102: 362: 27.33
+	Hs
		449266 LEG1_HUMAN (125-247): 3.18e-43: 144: 28.00		PTPRK_HUMAN (1998-2314): 2.28e-101: 362: 24.30
+	Hs
		119354 LEG9_HUMAN (108-249): 3.89e-40: 143: 37.67		PTPRJ_HUMAN (1995-2289): 4.87e-102: 362: 27.33
+	Hs
		119390 LEG9_HUMAN (108-249): 3.89e-40: 143: 37.67		PTPRK_HUMAN (1998-2314): 2.28e-101: 362: 24.30
+	Hs
		441165 LEG1_HUMAN (125-247): 3.18e-43: 144: 28.00		PTPRC_HUMAN (1337-2314): 1.65e-99: 354: 14.06
+	Hs
		449184 LEG1_HUMAN (125-247): 3.18e-43: 144: 28.00		PTPRA_HUMAN (2023-2314): 3.27e-103: 353: 26.33
+	Hs
		119150 LEG9_HUMAN (108-249): 3.89e-40: 143: 37.67		PTPRA_HUMAN (2023-2314): 3.27e-103: 353: 26.33
+	Hs
		121103 LEG8_HUMAN (105-245): 4.74e-39: 139: 36.11		PTPRA_HUMAN (2023-2314): 3.27e-103: 353: 26.33
+	Hs
		449192 LEG1_HUMAN (125-247): 3.18e-43: 144: 28.00		PTPRD_HUMAN (237-431): 1.55e-15: 85.5: 18.91