Protein: TRI22
E3 ubiquitin-protein ligase TRIM22 (EC 2.3.2.27) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (RING-type E3 ubiquitin transferase TRIM22) (Staf-50) (Tripartite motif-containing protein 22)

Gene: TRI22, TRIM22
Organism: Homo sapiens
Interactions: 30
UniProt ID: Q8IYM9

Gene Ontology (top 5):
GO:0002230 - positive regulation of defense response to virus by host
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

906702

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

Small-scale

0.778

High

714260

PML
Protein PML

2

20

High-throughput

0.754

High

1315290

TRI22
E3 ubiquitin-protein ligase TRIM22

1

15

Small-scale

0.647

High

1315294

PKHF2
Pleckstrin homology domain-containing family F member 2

2

9

High-throughput

0.606

High

1315295

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

2

14

Small-scale

0.605

High

401124

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

Small-scale

0.561

High

683484

IKBA
NF-kappa-B inhibitor alpha

1

9

Small-scale

0.561

High

168720

CSKP
Peripheral plasma membrane protein CASK

1

7

High-throughput

0.541

High

593156

CREB1
Cyclic AMP-responsive element-binding protein 1

1

3

High-throughput

0.541

High

1149851

TAF7
Transcription initiation factor TFIID subunit 7

1

1

High-throughput

0.541

High

1315292

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

7

High-throughput

0.541

High

1315293

CIC
Protein capicua homolog

1

4

High-throughput

0.541

High

1315297

RERE
Arginine-glutamic acid dipeptide repeats protein

1

3

High-throughput

0.541

High

1315298

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

4

High-throughput

0.536

High

1315020

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.518

High

127370

LEG8
Galectin-8

1

14

Small-scale

0.501

High

609740

LEG3
Galectin-3

1

14

Small-scale

0.501

High

177906

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.479

High

445576

IF4E
Eukaryotic translation initiation factor 4E

1

2

Small-scale

0.479

High

691788

MK03
Mitogen-activated protein kinase 3

1

2

Small-scale

0.479

High

703642

MK01
Mitogen-activated protein kinase 1

1

2

Small-scale

0.479

High

749485

C2TA
MHC class II transactivator

1

14

Small-scale

0.479

High

1088907

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1156677

NF2L2
Nuclear factor erythroid 2-related factor 2

1

1

Small-scale

0.479

High

1315291

KAT2A
Histone acetyltransferase KAT2A

1

7

Small-scale

0.479

High

1315296

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

11

Small-scale

0.479

High

1315299

NEMO
NF-kappa-B essential modulator

1

12

Small-scale

0.479

High

1276468

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

827840

STAT3
Signal transducer and activator of transcription 3

1

4

High-throughput

0.445

High


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Last updated: 11Aug2025