HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 193
+	Hs
		573655 PTN1_HUMAN (1-435): 0: 539: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		436151 PTN1_HUMAN (1-435): 0: 539: 100.00		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		573659 PTN1_HUMAN (1-435): 0: 539: 100.00		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		573644 PTN1_HUMAN (1-435): 0: 539: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545198 PTN1_HUMAN (1-435): 0: 539: 100.00		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		573643 PTN1_HUMAN (1-435): 0: 539: 100.00		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		120299 PTN1_HUMAN (1-435): 0: 539: 100.00		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		570514 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		436150 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		570523 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		545197 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		900420 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925235 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		436276 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		950951 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		893944 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545345 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		892338 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		915635 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120410 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98