Protein: DERL2
Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa)

Gene: DERL2
Organism: Homo sapiens
Interactions: 127
UniProt ID: Q9GZP9

Gene Ontology (top 5):
GO:0001967 - suckling behavior
GO:0005047 - signal recognition particle binding
GO:0005769 - early endosome
GO:0005770 - late endosome
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1414442

DERL1
Derlin-1

4

11

Small-scale

0.886

High

1386360

FAF2
FAS-associated factor 2

7

7

Small-scale

0.745

High

1287437

SYVN1
E3 ubiquitin-protein ligase synoviolin

6

8

Small-scale

0.721

High

1428319

AMFR
E3 ubiquitin-protein ligase AMFR

5

9

Small-scale

0.711

High

1428315

SE1L1
Protein sel-1 homolog 1

5

3

Small-scale

0.709

High

935105

TERA
Transitional endoplasmic reticulum ATPase

4

5

Small-scale

0.686

High

1428309

RTN4
Reticulon-4

3

7

High-throughput

0.662

High

1410656

SELS
Selenoprotein S

3

1

Small-scale

0.656

High

369397

A1AT
Alpha-1-antitrypsin

3

2

Small-scale

0.640

High

1105557

OS9
Protein OS-9

3

1

Small-scale

0.640

High

1027172

REEP5
Receptor expression-enhancing protein 5

2

3

High-throughput

0.628

High

1163611

RTN1
Reticulon-1

2

7

High-throughput

0.628

High

1412652

ESYT1
Extended synaptotagmin-1

2

3

High-throughput

0.611

High

1023976

EM55
55 kDa erythrocyte membrane protein

2

0

High-throughput

0.580

High

1357635

SFT2A
Vesicle transport protein SFT2A

2

0

High-throughput

0.580

High

1428304

UN93B
Protein unc-93 homolog B1

2

0

High-throughput

0.576

High

856908

BAG6
Large proline-rich protein BAG6

2

0

Small-scale

0.559

High

849034

PTN9
Tyrosine-protein phosphatase non-receptor type 9

2

3

High-throughput

0.553

High

141864

ACKR2
Atypical chemokine receptor 2

1

3

High-throughput

0.536

High

182763

GP182
G-protein coupled receptor 182

1

5

High-throughput

0.536

High

249660

SNX3
Sorting nexin-3

1

2

High-throughput

0.536

High

297263

PRAF3
PRA1 family protein 3

1

2

High-throughput

0.536

High

328998

RTN3
Reticulon-3

1

7

High-throughput

0.536

High

468777

HS90B
Heat shock protein HSP 90-beta

1

2

High-throughput

0.536

High

564345

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

596710

NCPR
NADPH--cytochrome P450 reductase

1

2

High-throughput

0.536

High

611332

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

3

High-throughput

0.536

High

669066

FPR2
N-formyl peptide receptor 2

1

6

High-throughput

0.536

High

733067

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

1

High-throughput

0.536

High

863547

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

High-throughput

0.536

High

959397

RAP1B
Ras-related protein Rap-1b

1

2

High-throughput

0.536

High

1111970

SNX1
Sorting nexin-1

1

2

High-throughput

0.536

High

1114241

CUL3
Cullin-3

1

1

High-throughput

0.536

High

1136352

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.536

High

1291485

RETR3
Reticulophagy regulator 3

1

2

High-throughput

0.536

High

1330387

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.536

High

1365053

UBXN4
UBX domain-containing protein 4

1

5

High-throughput

0.536

High

1382184

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

1388091

ERLEC
Endoplasmic reticulum lectin 1

1

3

High-throughput

0.536

High

1393076

CREL1
Protein disulfide isomerase CRELD1

1

1

High-throughput

0.536

High

1428318

CLC2D
C-type lectin domain family 2 member D

1

1

High-throughput

0.536

High

950396

KR107
Keratin-associated protein 10-7

1

3

High-throughput

0.523

High

950674

KR108
Keratin-associated protein 10-8

1

2

High-throughput

0.523

High

125052

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.513

High

418423

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.513

High

631459

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.513

High

958016

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.513

High

1110059

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.513

High

1315127

EXOC8
Exocyst complex component 8

1

0

High-throughput

0.513

High

1325914

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1381710

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.513

High

1409657

CND3
Condensin complex subunit 3

1

0

High-throughput

0.513

High

1428312

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.513

High

1428313

EMC3
ER membrane protein complex subunit 3

1

0

High-throughput

0.513

High

1428317

NAT8B
N-acetyltransferase 8B

1

0

High-throughput

0.513

High

1428321

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

0

High-throughput

0.513

High

166037

FFAR1
Free fatty acid receptor 1

1

9

High-throughput

0.489

High

351962

S1PR4
Sphingosine 1-phosphate receptor 4

1

4

High-throughput

0.489

High

771229

APJ
Apelin receptor

1

1

High-throughput

0.489

High

820580

GPV
Platelet glycoprotein V

1

1

High-throughput

0.489

High

833867

P2RY2
P2Y purinoceptor 2

1

6

High-throughput

0.489

High

868312

P2RY1
P2Y purinoceptor 1

1

6

High-throughput

0.489

High

907056

CCR6
C-C chemokine receptor type 6

1

2

High-throughput

0.489

High

1112985

CUL2
Cullin-2

1

1

High-throughput

0.489

High

1212300

TM63B
Mechanosensitive cation channel TMEM63B

1

1

High-throughput

0.489

High

1291889

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

6

High-throughput

0.489

High

1366220

LPAR1
Lysophosphatidic acid receptor 1

1

4

High-throughput

0.489

High

1392526

GWL
Serine/threonine-protein kinase greatwall

1

1

High-throughput

0.489

High

1428302

S22A4
Solute carrier family 22 member 4

1

2

High-throughput

0.489

High

1428306

LPAR2
Lysophosphatidic acid receptor 2

1

3

High-throughput

0.489

High

1428307

GPR35
G-protein coupled receptor 35

1

5

High-throughput

0.489

High

1428311

GP173
Probable G-protein coupled receptor 173

1

1

High-throughput

0.489

High

48255

TM129
E3 ubiquitin-protein ligase TM129

1

1

Small-scale

0.479

High

48778

ESYT2
Extended synaptotagmin-2

1

3

High-throughput

0.479

High

178387

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

184508

SURF4
Surfeit locus protein 4

1

1

Small-scale

0.479

High

389884

TTHY
Transthyretin

1

2

Small-scale

0.479

High

404400

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

770786

PGH2
Prostaglandin G/H synthase 2

1

1

Small-scale

0.479

High

956188

SRP54
Signal recognition particle subunit SRP54

1

3

Small-scale

0.479

High

962453

RHOA
Transforming protein RhoA

1

2

High-throughput

0.479

High

963129

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

3

Small-scale

0.479

High

1041268

CAV1
Caveolin-1

1

1

Small-scale

0.479

High

1098129

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

Small-scale

0.479

High

1136684

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

2

Small-scale

0.479

High

1149265

SHH
Sonic hedgehog protein

1

1

Small-scale

0.479

High

1408197

RNF5
E3 ubiquitin-protein ligase RNF5

1

10

Small-scale

0.479

High

1428322

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

6

Small-scale

0.479

High

1252970

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1365503

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.458

High

1385197

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

Small-scale

0.458

High

104227

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.445

High

211178

CTR4
Cationic amino acid transporter 4

1

3

High-throughput

0.445

High

386204

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.439

High

949993

KR103
Keratin-associated protein 10-3

1

2

High-throughput

0.439

High

1238810

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1313830

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1428314

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

1

Small-scale

0.437

High

1428323

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

1

Small-scale

0.437

High

256141

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

652249

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

1

High-throughput

0.407

High

754092

CD80
T-lymphocyte activation antigen CD80

1

1

High-throughput

0.407

High

1308963

S22A9
Organic anion transporter 7

1

2

High-throughput

0.407

High

1322239

RBFA
Putative ribosome-binding factor A, mitochondrial

2

0

High-throughput

0.316

High

1428303

FXYD6
FXYD domain-containing ion transport regulator 6

2

0

High-throughput

0.316

High

1428310

DBLOH
Diablo IAP-binding mitochondrial protein

2

0

High-throughput

0.316

High

219361

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.279

Low

289337

FCN3
Ficolin-3

1

0

High-throughput

0.279

Low

349559

TSN15
Tetraspanin-15

1

0

High-throughput

0.279

Low

471236

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.279

Low

617590

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.279

Low

702842

5HT2C
5-hydroxytryptamine receptor 2C

1

0

High-throughput

0.279

Low

720798

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.279

Low

749392

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

906926

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.279

Low

1031535

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.279

Low

1251684

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1310387

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1350884

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1399605

OPALI
Opalin

1

0

High-throughput

0.279

Low

1413484

AASD1
Alanyl-tRNA editing protein Aarsd1

1

0

High-throughput

0.279

Low

1428308

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

0

High-throughput

0.279

Low

1428320

FZD1
Frizzled-1

1

0

High-throughput

0.279

Low

218744

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

437335

K2C8
Keratin, type II cytoskeletal 8

1

0

Small-scale

0.249

Low

1428305

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1428316

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025