HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: RHG12 (Q8IWW6)
Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12)
Gene: ARHGAP12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	32877691, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 435 Hs			1 846
+	Hs
		573891 PTN1_HUMAN (1-435): 0: 539: 100.00		RHG39_HUMAN (92-844): 1.04e-80: 283: 14.42
+	Hs
		983527 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		RHG26_HUMAN (382-844): 2.29e-81: 280: 20.46
+	Hs
		506512 PTN1_HUMAN (1-435): 0: 539: 100.00		BCR_HUMAN (632-819): 7.58e-25: 113: 39.27
+	Hs
		49636 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		RHG10_HUMAN (387-844): 1.32e-70: 250: 19.30
+	Hs
		64707 PTPRK_HUMAN (6-279): 1.27e-61: 218: 25.18		RHG32_HUMAN (603-844): 6.16e-73: 263: 30.00
+	Hs
		1022686 PTPRU_HUMAN (341-434): 6.63e-17: 85.4: 13.59		RHG05_HUMAN (302-844): 2.73e-73: 264: 19.08
+	Hs
		506517 PTN3_HUMAN (3-275): 1.72e-49: 182: 36.43		BCR_HUMAN (632-819): 7.58e-25: 113: 39.27
+	Hs
		506521 PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48		BCR_HUMAN (632-819): 7.58e-25: 113: 39.27