Protein: CCNB1
G2/mitotic-specific cyclin-B1

Gene: CCNB1
Organism: Homo sapiens
Interactions: 221
UniProt ID: P14635

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000922 - spindle pole
GO:0000940 - outer kinetochore
GO:0001556 - oocyte maturation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

443152

CDK1
Cyclin-dependent kinase 1

55

20

Small-scale

0.996

High

573751

CDK2
Cyclin-dependent kinase 2

15

20

Small-scale

0.985

High

573802

CDK5
Cyclin-dependent kinase 5

9

20

High-throughput

0.976

High

573769

CDN1A
Cyclin-dependent kinase inhibitor 1

8

15

Small-scale

0.967

High

573772

CDN1B
Cyclin-dependent kinase inhibitor 1B

6

15

Small-scale

0.948

High

573880

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

5

12

Small-scale

0.936

High

573777

CDK7
Cyclin-dependent kinase 7

4

20

Small-scale

0.899

High

573759

WEE1
Wee1-like protein kinase

2

9

Small-scale

0.799

High

573776

CDN1C
Cyclin-dependent kinase inhibitor 1C

2

15

Small-scale

0.789

High

573801

CDK3
Cyclin-dependent kinase 3

2

20

Small-scale

0.789

High

573812

CDC20
Cell division cycle protein 20 homolog

34

20

Small-scale

0.770

High

573909

FZR1
Fizzy-related protein homolog

33

20

Small-scale

0.770

High

573771

CCNF
Cyclin-F

2

6

Small-scale

0.754

High

573805

H11
Histone H1.1

7

7

Small-scale

0.742

High

573758

CDC27
Cell division cycle protein 27 homolog

7

8

Small-scale

0.738

High

573763

CKS2
Cyclin-dependent kinases regulatory subunit 2

6

20

Small-scale

0.735

High

573785

CKS1
Cyclin-dependent kinases regulatory subunit 1

5

20

Small-scale

0.718

High

573780

CCNH
Cyclin-H

1

6

High-throughput

0.691

High

573836

PKN2
Serine/threonine-protein kinase N2

1

4

High-throughput

0.691

High

573808

FOXM1
Forkhead box protein M1

4

2

Small-scale

0.683

High

550819

PCNA
Proliferating cell nuclear antigen

3

1

Small-scale

0.667

High

573854

ZC3C1
Zinc finger C3HC-type protein 1

4

0

Small-scale

0.666

High

555849

CADH1
Cadherin-1

3

3

Small-scale

0.655

High

573760

MPIP1
M-phase inducer phosphatase 1

3

9

Small-scale

0.650

High

573825

ESPL1
Separin

4

0

Small-scale

0.649

High

573906

APC4
Anaphase-promoting complex subunit 4

3

2

Small-scale

0.640

High

573874

NACC1
Nucleus accumbens-associated protein 1

2

1

Small-scale

0.639

High

573879

GA2L1
GAS2-like protein 1

3

0

High-throughput

0.638

High

573822

PTC1
Protein patched homolog 1

3

0

Small-scale

0.636

High

573891

IKZF5
Zinc finger protein Pegasus

3

0

High-throughput

0.634

High

573768

BRCA1
Breast cancer type 1 susceptibility protein

2

1

Small-scale

0.629

High

240648

PRKN
E3 ubiquitin-protein ligase parkin

2

3

Small-scale

0.624

High

573831

STK38
Serine/threonine-protein kinase 38

1

6

Small-scale

0.618

High

573856

VRK3
Serine/threonine-protein kinase VRK3

1

5

High-throughput

0.618

High

573870

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

Small-scale

0.614

High

573778

FXR1
RNA-binding protein FXR1

2

1

High-throughput

0.611

High

573817

SKP2
S-phase kinase-associated protein 2

2

4

Small-scale

0.611

High

573868

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

3

Small-scale

0.611

High

573916

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

2

1

Small-scale

0.611

High

442569

RB
Retinoblastoma-associated protein

2

7

Small-scale

0.602

High

573745

H15
Histone H1.5

2

7

Small-scale

0.602

High

240048

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

0

High-throughput

0.602

High

573837

LRRF1
Leucine-rich repeat flightless-interacting protein 1

2

0

High-throughput

0.602

High

573893

NGB
Neuroglobin

2

0

High-throughput

0.602

High

573897

PARVA
Alpha-parvin

2

0

High-throughput

0.602

High

573781

MAT1
CDK-activating kinase assembly factor MAT1

2

1

High-throughput

0.601

High

573796

SKP1
S-phase kinase-associated protein 1

2

3

High-throughput

0.601

High

573755

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

3

Small-scale

0.595

High

573782

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

5

Small-scale

0.595

High

573818

SQSTM
Sequestosome-1

2

1

Small-scale

0.595

High

573810

NCBP1
Nuclear cap-binding protein subunit 1

2

0

High-throughput

0.585

High

573866

KAT6A
Histone acetyltransferase KAT6A

2

0

High-throughput

0.585

High

345321

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

Small-scale

0.584

High

464781

SP1
Transcription factor Sp1

2

2

Small-scale

0.584

High

573761

MPIP2
M-phase inducer phosphatase 2

2

9

Small-scale

0.584

High

573783

TERA
Transitional endoplasmic reticulum ATPase

2

1

High-throughput

0.584

High

573793

H4
Histone H4

2

2

Small-scale

0.584

High

573838

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

3

Small-scale

0.578

High

573842

OTU7B
OTU domain-containing protein 7B

1

1

Small-scale

0.578

High

573873

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

1

Small-scale

0.578

High

573862

PTGR3
Prostaglandin reductase 3

2

1

High-throughput

0.574

High

573832

RBP1
RalA-binding protein 1

1

1

Small-scale

0.573

High

557824

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.561

High

573798

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

Small-scale

0.561

High

573811

EP300
Histone acetyltransferase p300

1

6

Small-scale

0.561

High

573888

CDT1
DNA replication factor Cdt1

1

2

Small-scale

0.561

High

573889

TSYL2
Testis-specific Y-encoded-like protein 2

1

4

Small-scale

0.561

High

573912

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

2

Small-scale

0.561

High

219597

B2L11
Bcl-2-like protein 11

2

0

Small-scale

0.559

High

573824

DCTN1
Dynactin subunit 1

2

0

High-throughput

0.559

High

289068

DEDD
Death effector domain-containing protein

1

1

Small-scale

0.554

High

573869

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

408648

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

Small-scale

0.537

High

573770

CUX1
Homeobox protein cut-like 1

1

2

Small-scale

0.536

High

276423

PDCD6
Programmed cell death protein 6

1

1

High-throughput

0.536

High

570346

GFAP
Glial fibrillary acidic protein

1

1

High-throughput

0.536

High

573754

STOM
Stomatin

1

1

High-throughput

0.536

High

573757

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

2

High-throughput

0.536

High

573807

PRDX1
Peroxiredoxin-1

1

2

High-throughput

0.536

High

573809

RBL2
Retinoblastoma-like protein 2

1

7

High-throughput

0.536

High

573844

KLC3
Kinesin light chain 3

1

1

High-throughput

0.536

High

573878

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

279273

TULP3
Tubby-related protein 3

1

0

High-throughput

0.518

High

573775

TSC2
Tuberin

1

1

Small-scale

0.515

High

573786

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

2

Small-scale

0.515

High

573865

TSC1
Hamartin

1

1

Small-scale

0.515

High

573850

UBE3D
E3 ubiquitin-protein ligase E3D

1

0

Small-scale

0.513

High

60487

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

1

0

High-throughput

0.513

High

66866

SPDE4
Speedy protein E4

1

0

High-throughput

0.513

High

171394

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.513

High

217248

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.513

High

570823

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

573820

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

573823

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.513

High

573826

KIF22
Kinesin-like protein KIF22

1

0

High-throughput

0.513

High

573829

MD2BP
MAD2L1-binding protein

1

0

High-throughput

0.513

High

573841

TUT7
Terminal uridylyltransferase 7

1

0

High-throughput

0.513

High

573843

L2GL2
LLGL scribble cell polarity complex component 2

1

0

High-throughput

0.513

High

573848

CHSTF
Carbohydrate sulfotransferase 15

1

0

High-throughput

0.513

High

573853

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

573867

ALKB8
tRNA

1

0

High-throughput

0.513

High

573902

HOP2
Homologous-pairing protein 2 homolog

1

0

High-throughput

0.513

High

573915

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

0

High-throughput

0.513

High

185404

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

186691

P73
Tumor protein p73

1

3

Small-scale

0.501

High

222683

PRC1
Protein regulator of cytokinesis 1

1

2

Small-scale

0.501

High

275450

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

1

2

Small-scale

0.501

High

332134

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

2

Small-scale

0.501

High

487969

DPOLA
DNA polymerase alpha catalytic subunit

1

2

Small-scale

0.501

High

573743

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

1

Small-scale

0.501

High

573750

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

2

Small-scale

0.501

High

573756

ARI4A
AT-rich interactive domain-containing protein 4A

1

1

Small-scale

0.501

High

573762

MPIP3
M-phase inducer phosphatase 3

1

9

Small-scale

0.501

High

573767

TGFR2
TGF-beta receptor type-2

1

1

Small-scale

0.501

High

573773

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

Small-scale

0.501

High

573787

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

1

Small-scale

0.501

High

573794

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

1

Small-scale

0.501

High

573800

XIAP
E3 ubiquitin-protein ligase XIAP

1

4

Small-scale

0.501

High

573881

CDC6
Cell division control protein 6 homolog

1

8

Small-scale

0.501

High

573900

APC11
Anaphase-promoting complex subunit 11

1

2

Small-scale

0.501

High

573905

HERC5
E3 ISG15--protein ligase HERC5

1

2

Small-scale

0.501

High

573885

DPY30
Protein dpy-30 homolog

1

0

High-throughput

0.493

High

573833

UBE3C
Ubiquitin-protein ligase E3C

1

1

Small-scale

0.489

High

303073

ZFAN5
AN1-type zinc finger protein 5

1

0

Small-scale

0.480

High

573797

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.480

High

573799

BTG2
Protein BTG2

1

0

Small-scale

0.480

High

573813

TP53B
TP53-binding protein 1

1

0

Small-scale

0.480

High

573827

IMB1
Importin subunit beta-1

1

0

Small-scale

0.480

High

58695

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

3

High-throughput

0.479

High

143389

E2F3
Transcription factor E2F3

1

9

Small-scale

0.479

High

172445

XPO1
Exportin-1

1

5

High-throughput

0.479

High

221233

DCX
Neuronal migration protein doublecortin

1

1

Small-scale

0.479

High

289919

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.479

High

315078

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

321169

ERLN2
Erlin-2

1

1

Small-scale

0.479

High

323149

TRI37
E3 ubiquitin-protein ligase TRIM37

1

3

High-throughput

0.479

High

413114

P53
Cellular tumor antigen p53

1

3

Small-scale

0.479

High

488391

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

1

Small-scale

0.479

High

541309

FGFR1
Fibroblast growth factor receptor 1

1

1

High-throughput

0.479

High

573744

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

573747

FLNA
Filamin-A

1

1

Small-scale

0.479

High

573748

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

573749

NFYA
Nuclear transcription factor Y subunit alpha

1

1

Small-scale

0.479

High

573752

NFYB
Nuclear transcription factor Y subunit beta

1

1

Small-scale

0.479

High

573764

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

573765

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

8

High-throughput

0.479

High

573766

SRBP1
Sterol regulatory element-binding protein 1

1

1

Small-scale

0.479

High

573779

BRCA2
Breast cancer type 2 susceptibility protein

1

2

Small-scale

0.479

High

573784

PSA6
Proteasome subunit alpha type-6

1

2

Small-scale

0.479

High

573788

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

8

High-throughput

0.479

High

573789

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.479

High

573790

RS14
Small ribosomal subunit protein uS11

1

1

Small-scale

0.479

High

573803

SET
Protein SET

1

4

Small-scale

0.479

High

573814

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

Small-scale

0.479

High

573815

CDC16
Cell division cycle protein 16 homolog

1

8

Small-scale

0.479

High

573816

TIF1B
Transcription intermediary factor 1-beta

1

4

Small-scale

0.479

High

573819

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.479

High

573821

CUL3
Cullin-3

1

3

Small-scale

0.479

High

573828

NUMA1
Nuclear mitotic apparatus protein 1

1

1

Small-scale

0.479

High

573830

PCM1
Pericentriolar material 1 protein

1

1

High-throughput

0.479

High

573835

CCDC6
Coiled-coil domain-containing protein 6

1

1

Small-scale

0.479

High

573839

CE170
Centrosomal protein of 170 kDa

1

1

High-throughput

0.479

High

573846

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

573847

CE128
Centrosomal protein of 128 kDa

1

1

High-throughput

0.479

High

573852

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

4

Small-scale

0.479

High

573855

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

1

Small-scale

0.479

High

573858

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

1

Small-scale

0.479

High

573861

NIN
Ninein

1

1

High-throughput

0.479

High

573877

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.479

High

573882

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

1

Small-scale

0.479

High

573890

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

573894

TRI36
E3 ubiquitin-protein ligase TRIM36

1

7

High-throughput

0.479

High

573895

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

Small-scale

0.479

High

573903

ZO2
Tight junction protein 2

1

1

High-throughput

0.479

High

573904

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

573910

APC10
Anaphase-promoting complex subunit 10

1

1

Small-scale

0.479

High

573911

CC14A
Dual specificity protein phosphatase CDC14A

1

3

Small-scale

0.479

High

573913

EXO1
Exonuclease 1

1

7

Small-scale

0.479

High

573914

FBW1A
F-box/WD repeat-containing protein 1A

1

2

Small-scale

0.479

High

159494

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

322695

RHBT3
Rho-related BTB domain-containing protein 3

1

0

Small-scale

0.458

High

573746

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

573753

DNMT1
DNA

1

0

Small-scale

0.458

High

573791

RS18
Small ribosomal subunit protein uS13

1

0

Small-scale

0.458

High

573792

RHOB
Rho-related GTP-binding protein RhoB

1

0

High-throughput

0.458

High

573795

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

Small-scale

0.458

High

573806

TF65
Transcription factor p65

1

0

Small-scale

0.458

High

573834

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

573840

CE162
Centrosomal protein of 162 kDa

1

0

High-throughput

0.458

High

573849

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

573851

CNTRL
Centriolin

1

0

High-throughput

0.458

High

573857

MFN1
Mitofusin-1

1

0

Small-scale

0.458

High

573859

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

573860

RPTOR
Regulatory-associated protein of mTOR

1

0

Small-scale

0.458

High

573864

FBF1
Fas-binding factor 1

1

0

High-throughput

0.458

High

573875

CIC
Protein capicua homolog

1

0

High-throughput

0.458

High

573876

DCR1C
Protein artemis

1

0

Small-scale

0.458

High

573883

WAC
WW domain-containing adapter protein with coiled-coil

1

0

Small-scale

0.458

High

573886

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

573887

APC1
Anaphase-promoting complex subunit 1

1

0

Small-scale

0.458

High

573896

TREX1
Three-prime repair exonuclease 1

1

0

Small-scale

0.458

High

573898

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.458

High

573899

BCLF1
Bcl-2-associated transcription factor 1

1

0

Small-scale

0.458

High

573901

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

573907

JUPI1
Jupiter microtubule associated homolog 1

1

0

Small-scale

0.458

High

429230

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

573871

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.445

High

463894

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

1

High-throughput

0.437

High

573804

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

3

High-throughput

0.437

High

573845

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

134433

EF2K
Eukaryotic elongation factor 2 kinase

1

0

Small-scale

0.426

High

442993

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

Small-scale

0.426

High

573884

HIRP3
HIRA-interacting protein 3

1

0

High-throughput

0.426

High

573908

FBX3
F-box only protein 3

1

0

High-throughput

0.426

High

96994

E9PJN9
Ribosomal protein S3

1

1

High-throughput

0.407

High

573774

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

388765

C1QC
Complement C1q subcomponent subunit C

1

0

High-throughput

0.279

Low

573863

F110D
Protein FAM110D

1

0

High-throughput

0.279

Low

573872

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.279

Low

573892

CIP1
E3 ubiquitin-protein ligase CCNB1IP1

1

0

Small-scale

0.265

Low

466997

DAF
Complement decay-accelerating factor

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025