HitPredict

Interactor 1: PTPRA (P18052)
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28)
Gene: PTPRA

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	23452850, 7518772
Identification Methods	anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0008286 - insulin receptor signaling pathway GO:0016020 - membrane GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 829 Mm			1 217
+	Hs
		577009 PTPRA_HUMAN (1-829): 0: 973: 89.50		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Mm
		574000 PTPRA_MOUSE (1-829): 0: 1004: 100.00		FYN_MOUSE (161-215): 4.88e-13: 69.2: 31.58
+	Mm
		403413 PTPRA_MOUSE (1-829): 0: 1004: 100.00		SRC_MOUSE (80-215): 1.5e-10: 61.9: 17.24
+	Rn
		1144045 Q66HJ7_RAT (1-829): 0: 986: 92.55		FYN_RAT (161-215): 4.88e-13: 69.2: 31.58
+	Rn
		1146020 Q66HJ7_RAT (1-829): 0: 986: 92.55		SRC_RAT (104-215): 7.57e-12: 65.7: 19.30
+	Hs
		411997 PTPRA_HUMAN (1-829): 0: 973: 89.50		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Rn
		976063 PTPRA_RAT (1-829): 0: 970: 91.59		SRC_RAT (104-215): 7.57e-12: 65.7: 19.30
+	Hs
		522756 PTPRA_HUMAN (1-829): 0: 973: 89.50		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		617047 PTPRE_HUMAN (112-829): 0: 810: 61.79		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		146925 PTPRT_HUMAN (2-822): 0: 794: 28.24		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		411565 PTPRF_HUMAN (4-827): 0: 866: 38.43		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Hs
		412016 PTPRD_HUMAN (14-827): 0: 885: 37.97		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		411609 PTPRM_HUMAN (2-822): 0: 808: 29.15		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Mm
		56907 PTPRF_MOUSE (4-827): 0: 875: 37.71		FYN_MOUSE (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		411959 PTPRF_HUMAN (4-827): 0: 866: 38.43		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		411728 PTPRK_HUMAN (3-821): 0: 794: 29.08		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Dm
		337644 LAR_DROME (58-827): 0: 827: 36.39		ABL_DROME (4-135): 1.01e-22: 97.4: 37.68
+	Hs
		782790 PTPRK_HUMAN (3-821): 0: 794: 29.08		CSK_HUMAN (2-139): 4.25e-24: 100: 36.24
+	Hs
		412017 PTPRE_HUMAN (112-829): 0: 810: 61.79		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		433255 PTPRE_HUMAN (112-829): 0: 810: 61.79		YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37