Interactor 1: ERCC2 (P18074)
General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 3.6.4.12) (Basic transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum group D-complementing protein)
Gene: ERCC2

Interactor 2: TF2H1 (P32780)
General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit)
Gene: GTF2H1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.928

The method score is based on:

Property Details
Experiments 26340423, 9130708, 8152490, 11071939, 8652557
Identification Methods pull down, affinity chromatography technology, coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains BSD~Helicase_C_2
Common GO terms GO:0000439 - transcription factor TFIIH core complex
GO:0005654 - nucleoplasm
GO:0005675 - transcription factor TFIIH holo complex
GO:0006289 - nucleotide-excision repair
GO:0006366 - transcription by RNA polymerase II
and 1 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 760
Hs

1 548
+ At
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024