Protein: FIS1
Mitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11)

Gene: FIS1
Organism: Homo sapiens
Interactions: 211
UniProt ID: Q9Y3D6

Gene Ontology (top 5):
GO:0000266 - mitochondrial fission
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005777 - peroxisome
GO:0005778 - peroxisomal membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

904215

BAP31
B-cell receptor-associated protein 31

1

0

Small-scale

0.731

High

135741

DNM1L
Dynamin-1-like protein

4

5

Small-scale

0.694

High

1447118

MID51
Mitochondrial dynamics protein MIEF1

3

0

Small-scale

0.628

High

1349354

TBC15
TBC1 domain family member 15

3

2

Small-scale

0.615

High

1401534

VP13A
Intermembrane lipid transfer protein VPS13A

2

2

High-throughput

0.611

High

1437454

TBC17
TBC1 domain family member 17

2

2

High-throughput

0.611

High

194765

FFAR2
Free fatty acid receptor 2

2

0

High-throughput

0.580

High

1242822

RNK
Ribonuclease kappa

2

0

High-throughput

0.580

High

1254323

TMPPE
Transmembrane protein with metallophosphoesterase domain

2

0

High-throughput

0.580

High

1326955

EMC5
ER membrane protein complex subunit 5

2

0

High-throughput

0.580

High

1328230

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

1384652

APH1A
Gamma-secretase subunit APH-1A

2

0

High-throughput

0.580

High

1396416

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.580

High

1414839

ABHD6
Monoacylglycerol lipase ABHD6

2

0

High-throughput

0.580

High

1452337

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.580

High

1490572

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.580

High

1491204

FIS1
Mitochondrial fission 1 protein

1

2

Small-scale

0.575

High

230473

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.565

High

1438571

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

0

Small-scale

0.549

High

896336

PEX5
Peroxisomal targeting signal 1 receptor

2

0

Small-scale

0.539

High

538720

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.536

High

574130

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

1

High-throughput

0.536

High

1380915

RAB24
Ras-related protein Rab-24

1

1

High-throughput

0.536

High

1462586

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

1

High-throughput

0.536

High

1491205

RBGP1
Rab GTPase-activating protein 1

1

2

High-throughput

0.536

High

274843

PX11A
Peroxisomal membrane protein 11A

1

3

Small-scale

0.515

High

354482

PX11B
Peroxisomal membrane protein 11B

1

3

Small-scale

0.515

High

1392971

PX11C
Peroxisomal membrane protein 11C

1

3

Small-scale

0.515

High

227035

MCAT
Mitochondrial carnitine/acylcarnitine carrier protein

1

0

High-throughput

0.513

High

931317

AT12A
Potassium-transporting ATPase alpha chain 2

1

0

High-throughput

0.513

High

956627

RAB5B
Ras-related protein Rab-5B

1

0

High-throughput

0.513

High

958055

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.513

High

1132471

CASP8
Caspase-8

1

0

Small-scale

0.513

High

1310554

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1325956

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1363259

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

1363901

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.513

High

1381788

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.513

High

1395048

SPTCS
Spatacsin

1

0

High-throughput

0.513

High

1437623

NJMU
Protein Njmu-R1

1

0

High-throughput

0.513

High

1445945

RAB18
Ras-related protein Rab-18

1

0

High-throughput

0.513

High

1451793

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.493

High

1216542

BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

1

1

High-throughput

0.489

High

1231296

BLT3A
Bridge-like lipid transfer protein family member 3A

1

2

High-throughput

0.489

High

1386111

EVI5L
EVI5-like protein

1

1

High-throughput

0.489

High

1410643

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.489

High

713147

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.486

High

183986

S22A2
Solute carrier family 22 member 2

1

1

Small-scale

0.481

High

184032

S22A1
Solute carrier family 22 member 1

1

1

Small-scale

0.481

High

192347

YKT6
Synaptobrevin homolog YKT6

1

1

High-throughput

0.479

High

209146

CYB5B
Cytochrome b5 type B

1

1

High-throughput

0.479

High

231784

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.479

High

243368

PRKN
E3 ubiquitin-protein ligase parkin

1

1

Small-scale

0.479

High

281695

MTX2
Metaxin-2

1

1

High-throughput

0.479

High

318075

TOM70
Mitochondrial import receptor subunit TOM70

1

1

High-throughput

0.479

High

444030

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

1

High-throughput

0.479

High

508878

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

Small-scale

0.479

High

568869

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

High-throughput

0.479

High

605860

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

High-throughput

0.479

High

621547

HXK1
Hexokinase-1

1

1

High-throughput

0.479

High

725570

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

1

High-throughput

0.479

High

828475

PEX19
Peroxisomal biogenesis factor 19

1

1

High-throughput

0.479

High

914141

HXK2
Hexokinase-2

1

1

High-throughput

0.479

High

1112277

PEX6
Peroxisomal ATPase PEX6

1

2

High-throughput

0.479

High

1125747

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

High-throughput

0.479

High

1147758

MTFR1
Mitochondrial fission regulator 1

1

2

High-throughput

0.479

High

1204967

MTX3
Metaxin-3

1

1

High-throughput

0.479

High

1209826

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

Small-scale

0.479

High

1216568

VP13D
Intermembrane lipid transfer protein VPS13D

1

2

High-throughput

0.479

High

1242137

MTFR2
Mitochondrial fission regulator 2

1

2

High-throughput

0.479

High

1272037

ARMX2
Armadillo repeat-containing X-linked protein 2

1

2

High-throughput

0.479

High

1324256

ARM10
Armadillo repeat-containing protein 10

1

2

High-throughput

0.479

High

1328009

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

1

High-throughput

0.479

High

1334270

ATAD1
Outer mitochondrial transmembrane helix translocase

1

2

High-throughput

0.479

High

1365086

UBXN4
UBX domain-containing protein 4

1

1

High-throughput

0.479

High

1366637

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

1392704

MYO19
Unconventional myosin-XIX

1

1

High-throughput

0.479

High

1403755

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.479

High

1405824

TTC1
Tetratricopeptide repeat protein 1

1

1

High-throughput

0.479

High

1429336

MFR1L
Mitochondrial fission regulator 1-like

1

2

High-throughput

0.479

High

1452981

CISD1
CDGSH iron-sulfur domain-containing protein 1

1

1

High-throughput

0.479

High

1453944

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

1

High-throughput

0.479

High

1459682

ARMX3
Armadillo repeat-containing X-linked protein 3

1

2

High-throughput

0.479

High

1490973

TDRKH
Tudor and KH domain-containing protein

1

1

High-throughput

0.479

High

1491206

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.479

High

60445

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.458

High

137852

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

251273

RNBP6
Ran-binding protein 6

1

0

High-throughput

0.458

High

275141

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

281122

TACC1
Transforming acidic coiled-coil-containing protein 1

1

0

High-throughput

0.458

High

292785

RENR
Renin receptor

1

0

High-throughput

0.458

High

329607

STBD1
Starch-binding domain-containing protein 1

1

0

High-throughput

0.458

High

418534

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

607255

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

611429

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

617625

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.458

High

648257

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.458

High

666250

KPCL
Protein kinase C eta type

1

0

High-throughput

0.458

High

701942

ABCD3
ATP-binding cassette sub-family D member 3

1

0

High-throughput

0.458

High

732867

GLPK
Glycerol kinase

1

0

High-throughput

0.458

High

774019

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.458

High

856997

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.458

High

880757

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

901699

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

906225

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

920914

ACLY
ATP-citrate synthase

1

0

High-throughput

0.458

High

941992

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

1061325

RHG01
Rho GTPase-activating protein 1

1

0

High-throughput

0.458

High

1103676

PHLP
Phosducin-like protein

1

0

High-throughput

0.458

High

1108308

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1112466

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

0

High-throughput

0.458

High

1114722

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1124951

FLOT2
Flotillin-2

1

0

High-throughput

0.458

High

1139424

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.458

High

1154792

VAMP3
Vesicle-associated membrane protein 3

1

0

High-throughput

0.458

High

1155288

VAS1
V-type proton ATPase subunit S1

1

0

High-throughput

0.458

High

1164633

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

1214609

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1215647

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.458

High

1218507

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.458

High

1221034

FBW10
F-box/WD repeat-containing protein 10

1

0

High-throughput

0.458

High

1224793

RN213
E3 ubiquitin-protein ligase RNF213

1

0

High-throughput

0.458

High

1258014

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

0

High-throughput

0.458

High

1275769

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

0

High-throughput

0.458

High

1278154

MAVS
Mitochondrial antiviral-signaling protein

1

0

High-throughput

0.458

High

1288829

KTN1
Kinectin

1

0

High-throughput

0.458

High

1294033

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.458

High

1294527

VRK2
Serine/threonine-protein kinase VRK2

1

0

High-throughput

0.458

High

1309922

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1312310

MIRO2
Mitochondrial Rho GTPase 2

1

0

High-throughput

0.458

High

1330448

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

1332677

MIGA1
Mitoguardin 1

1

0

High-throughput

0.458

High

1336699

EHBP1
EH domain-binding protein 1

1

0

High-throughput

0.458

High

1337734

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

1347948

GDAP1
Ganglioside-induced differentiation-associated protein 1

1

0

Small-scale

0.458

High

1357302

CHMP7
Charged multivesicular body protein 7

1

0

High-throughput

0.458

High

1367662

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1382256

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.458

High

1382472

SYAP1
Synapse-associated protein 1

1

0

High-throughput

0.458

High

1382985

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.458

High

1386645

OPTN
Optineurin

1

0

High-throughput

0.458

High

1393861

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1397586

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1402402

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.458

High

1402839

TM209
Transmembrane protein 209

1

0

High-throughput

0.458

High

1403832

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1405967

CDCA3
Cell division cycle-associated protein 3

1

0

High-throughput

0.458

High

1409625

NIPS1
Protein NipSnap homolog 1

1

0

High-throughput

0.458

High

1412734

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

1417003

B2L13
Bcl-2-like protein 13

1

0

High-throughput

0.458

High

1420438

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

1429153

MFF
Mitochondrial fission factor

1

0

High-throughput

0.458

High

1429591

LSG1
Large subunit GTPase 1 homolog

1

0

High-throughput

0.458

High

1432085

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.458

High

1432827

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.458

High

1433703

TRABD
TraB domain-containing protein

1

0

High-throughput

0.458

High

1438712

SENP2
Sentrin-specific protease 2

1

0

High-throughput

0.458

High

1439255

GPAT1
Glycerol-3-phosphate acyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1448130

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1450478

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1450515

DJC11
DnaJ homolog subfamily C member 11

1

0

High-throughput

0.458

High

1451762

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1453749

EMC3
ER membrane protein complex subunit 3

1

0

High-throughput

0.458

High

1459694

MLX
Max-like protein X

1

0

High-throughput

0.458

High

1459848

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.458

High

1460985

FBXL4
F-box/LRR-repeat protein 4

1

0

High-throughput

0.458

High

1461542

PALD
Paladin

1

0

High-throughput

0.458

High

1490934

MAN1
Inner nuclear membrane protein Man1

1

0

High-throughput

0.458

High

1491207

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.458

High

280378

SC22B
Vesicle-trafficking protein SEC22b

1

1

High-throughput

0.437

High

333266

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.437

High

355052

CHK2
Serine/threonine-protein kinase Chk2

1

1

High-throughput

0.437

High

1386426

FAF2
FAS-associated factor 2

1

1

High-throughput

0.437

High

67093

S38A8
Solute carrier family 38 member 8

1

0

High-throughput

0.426

High

1323789

S39AB
Zinc transporter ZIP11

1

0

High-throughput

0.426

High

870089

KCNJ6
G protein-activated inward rectifier potassium channel 2

2

0

High-throughput

0.316

High

943458

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

2

0

High-throughput

0.316

High

1102813

UT1
Urea transporter 1

2

0

High-throughput

0.316

High

1142978

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.316

High

1186075

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.316

High

1207657

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

1449826

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

1329459

KASH5
Protein KASH5

1

0

High-throughput

0.299

High

133214

QSOX1
Sulfhydryl oxidase 1

1

0

High-throughput

0.279

Low

1103861

TARB1
tRNA

1

0

High-throughput

0.279

Low

1206064

DYLT4
Dynein light chain Tctex-type 4

1

0

High-throughput

0.279

Low

1225989

F91A1
Protein FAM91A1

1

0

High-throughput

0.279

Low

1228896

ZFY26
Zinc finger FYVE domain-containing protein 26

1

0

High-throughput

0.279

Low

1230769

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.279

Low

1330643

CCYL1
Cyclin-Y-like protein 1

1

0

High-throughput

0.279

Low

1413521

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.279

Low

1437827

BRF2
Transcription factor IIIB 50 kDa subunit

1

0

High-throughput

0.279

Low

1490510

PLAP
Phospholipase A-2-activating protein

1

0

High-throughput

0.279

Low

369790

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.251

Low

1109100

AQP6
Aquaporin-6

1

0

High-throughput

0.251

Low

1410477

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low

1491208

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.251

Low

294569

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

937994

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

1111758

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.249

Low

1136423

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

1177128

INF2
Inverted formin-2

1

0

High-throughput

0.249

Low

1191815

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.249

Low

1210137

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.249

Low

1256217

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1353227

SMCR8
Guanine nucleotide exchange protein SMCR8

1

0

High-throughput

0.249

Low

1436990

SPE39
Spermatogenesis-defective protein 39 homolog

1

0

High-throughput

0.249

Low

1437527

WDR41
WD repeat-containing protein 41

1

0

High-throughput

0.249

Low

344378

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

1335438

SPX3
Sugar phosphate exchanger 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025