HitPredict - High confidence protein-protein interactions

Interactor 1: EGR1 (P18146)
Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24)
Gene: EGR1

Interactor 2: LEF1 (Q9UJU2)
Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha)
Gene: LEF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	20690147, 21743491
Identification Methods	anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific and 12 others more... GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0010628 - positive regulation of gene expression GO:0030509 - BMP signaling pathway GO:0043565 - sequence-specific DNA binding GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:1990837 - sequence-specific double-stranded DNA binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1	543
Hs

1	399

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024