Protein: PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1 (EC 3.1.3.16) (Calcineurin A1) (Calmodulin-binding protein 1)

Gene: PP2B1, CNA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 88
UniProt ID: P23287

Gene Ontology (top 5):
GO:0000747 - conjugation with cellular fusion
GO:0005516 - calmodulin binding
GO:0005737 - cytoplasm
GO:0005955 - calcineurin complex
GO:0006873 - intracellular monoatomic ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

449071

CALM
Calmodulin

8

18

Small-scale

0.968

High

656286

CANB
Calcineurin subunit B

7

20

Small-scale

0.965

High

575568

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

2

13

Small-scale

0.755

High

392258

HSP82
ATP-dependent molecular chaperone HSP82

2

4

Small-scale

0.737

High

656301

RCN1
Calcipressin-like protein

4

1

Small-scale

0.699

High

656312

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

6

Small-scale

0.647

High

656340

SLM2
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2

3

5

Small-scale

0.645

High

656302

ALY1
Arrestin-related trafficking adapter 6

2

4

Small-scale

0.644

High

656320

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

3

5

Small-scale

0.641

High

656285

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

1

13

Small-scale

0.621

High

656344

ROD1
Protein ROD1

2

4

Small-scale

0.619

High

656352

RGA2
Rho-type GTPase-activating protein 2

2

5

Small-scale

0.619

High

578877

HSC82
ATP-dependent molecular chaperone HSC82

1

4

Small-scale

0.618

High

656341

CRZ1
Transcriptional regulator CRZ1

2

3

Small-scale

0.606

High

656288

MAS5
Mitochondrial protein import protein MAS5

2

2

High-throughput

0.584

High

656361

HPH1
Protein HPH1

3

1

Small-scale

0.580

High

656319

SSB2
Ribosome-associated molecular chaperone SSB2

2

15

High-throughput

0.552

High

656293

MLF3
Protein MLF3

1

1

Small-scale

0.536

High

656297

ELM1
Serine/threonine-protein kinase ELM1

1

2

Small-scale

0.536

High

656347

DIG2
Down-regulator of invasive growth 2

1

1

Small-scale

0.536

High

656348

TDA1
Serine/threonine-protein kinase TDA1

1

10

Small-scale

0.536

High

656351

SKG3
Protein SKG3

1

1

Small-scale

0.536

High

598956

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

2

High-throughput

0.536

High

656300

SPT7
SAGA complex subunit SPT7

1

10

High-throughput

0.536

High

656313

SPT8
SAGA complex subunit SPT8

2

1

Small-scale

0.534

High

656290

AHC2
ADA histone acetyltransferase complex component 2

1

0

High-throughput

0.513

High

656322

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.513

High

656329

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.513

High

558590

CAF20
Cap-associated protein CAF20

1

2

Small-scale

0.501

High

656294

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

1

6

Small-scale

0.501

High

656307

KIC1
Serine/threonine-protein kinase KIC1

1

10

Small-scale

0.501

High

656323

RTS2
Zinc finger protein RTS2

1

1

Small-scale

0.501

High

656324

STB1
Protein STB1

1

1

Small-scale

0.501

High

656327

ALY2
Arrestin-related trafficking adapter 3

1

12

Small-scale

0.501

High

656333

INP52
Polyphosphatidylinositol phosphatase INP52

1

3

Small-scale

0.501

High

656350

LIC4
Protein ATC1/LIC4

1

1

Small-scale

0.501

High

656355

TFB6
General transcription and DNA repair factor IIH subunit TFB6

1

1

Small-scale

0.501

High

656356

RCN2
Regulator of calcineurin 2

1

1

Small-scale

0.501

High

656360

YP247
WD repeat-containing protein YPL247C

1

10

Small-scale

0.501

High

656304

AIM3
Altered inheritance of mitochondria protein 3

1

10

Small-scale

0.489

High

656306

UBX7
UBX domain-containing protein 7

1

5

Small-scale

0.489

High

656309

SFB3
SED5-binding protein 3

1

1

Small-scale

0.489

High

656314

UME6
Transcriptional regulatory protein UME6

1

1

Small-scale

0.489

High

656316

BOI2
BEM1-interacting protein 2

1

5

Small-scale

0.489

High

656338

ZRG17
Protein ZRG17

1

1

Small-scale

0.489

High

656353

ATG13
Autophagy-related protein 13

1

1

Small-scale

0.489

High

656303

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

10

High-throughput

0.489

High

656331

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

4

High-throughput

0.489

High

656345

GCN5
Histone acetyltransferase GCN5

1

8

High-throughput

0.489

High

656325

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

High-throughput

0.486

High

656287

HCM1
Forkhead transcription factor HCM1

1

1

Small-scale

0.481

High

564642

STE12
Protein STE12

1

0

Small-scale

0.480

High

656292

BMH1
Protein BMH1

1

8

Small-scale

0.479

High

656299

BMH2
Protein BMH2

1

8

Small-scale

0.479

High

656328

MTNB
Methylthioribulose-1-phosphate dehydratase

1

1

High-throughput

0.479

High

656321

MSL1
U2 small nuclear ribonucleoprotein B''

1

8

High-throughput

0.464

High

531606

RL4A
Large ribosomal subunit protein uL4A

1

2

Small-scale

0.457

High

656296

SRP40
Suppressor protein SRP40

1

7

Small-scale

0.457

High

656305

YB75
Uncharacterized protein YBR225W

1

2

Small-scale

0.457

High

656315

NUP60
Nucleoporin NUP60

1

1

Small-scale

0.457

High

656346

JIP4
Uncharacterized protein JIP4

1

3

Small-scale

0.457

High

656336

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.457

High

523103

HSP71
Heat shock protein SSA1

1

14

High-throughput

0.445

High

543862

SSB1
Ribosome-associated molecular chaperone SSB1

1

15

High-throughput

0.445

High

656308

SSZ1
Ribosome-associated complex subunit SSZ1

1

10

High-throughput

0.445

High

656317

HSP7E
Heat shock protein SSC3, mitochondrial

1

15

High-throughput

0.445

High

656318

FIR1
Factor interacting with REF2

1

2

Small-scale

0.439

High

656343

SLU7
Pre-mRNA-splicing factor SLU7

1

1

Small-scale

0.439

High

656310

RGD3
Rho-GTPase-activating protein RGD3

1

0

High-throughput

0.438

High

656291

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

656359

DBP10
ATP-dependent RNA helicase DBP10

1

7

High-throughput

0.437

High

656326

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

656339

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

656354

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

5

High-throughput

0.407

High

656357

HFI1
SAGA complex subunit HFI1

1

1

High-throughput

0.407

High

656311

SKN7
Transcription factor SKN7

1

0

Small-scale

0.292

High

656289

SGF29
SAGA complex subunit SGF29

1

0

High-throughput

0.279

Low

656334

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.279

Low

656335

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.279

Low

656337

SAY1
Steryl acetyl hydrolase 1

1

0

High-throughput

0.279

Low

656349

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

0

High-throughput

0.279

Low

656295

SMI1
Cell wall assembly regulator SMI1

1

0

Small-scale

0.251

Low

656298

PRP18
Pre-mRNA-splicing factor 18

1

0

Small-scale

0.251

Low

656330

YD186
Uncharacterized protein YDL186W

1

0

High-throughput

0.238

Low

656332

SPT20
SAGA complex subunit SPT20

1

0

High-throughput

0.232

Low

656342

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.232

Low

656358

JID1
J domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025