HitPredict

Interactor 1: VINC (P18206)
Vinculin (Metavinculin) (MV)
Gene: VCL

Interactor 2: TRIP6 (Q15654)
Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1)
Gene: TRIP6

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.663

Property	Details
Experiments	16189514, 21516116, 34079125
Identification Methods	two hybrid, proximity labelling technology, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1134 Hs			1 476
+	Hs
		575867 VINC_HUMAN (1-1134): 0: 893: 100.00		LIMD1_HUMAN (1-475): 1.08e-69: 236: 25.36
+	Hs
		575811 VINC_HUMAN (1-1134): 0: 893: 100.00		LPP_HUMAN (3-475): 1.2e-65: 224: 38.82
+	Hs
		575706 VINC_HUMAN (1-1134): 0: 893: 100.00		PAXI_HUMAN (258-395): 1.68e-28: 120: 25.90
+	Hs
		238947 VINC_HUMAN (1-1134): 0: 893: 100.00		LPXN_HUMAN (337-474): 2.2e-28: 117: 22.60
+	Gg
		517021 VINC_CHICK (1-1134): 0: 880: 93.30		PAXI_CHICK (3-395): 5.69e-28: 118: 14.36
+	Hs
		575748 VINC_HUMAN (1-1134): 0: 893: 100.00		ZYX_HUMAN (91-467): 2.51e-15: 80.4: 18.02
+	Hs
		200161 VINC_HUMAN (1-1134): 0: 893: 100.00		TGFI1_HUMAN (268-337): 1.32e-11: 68.3: 27.14
+	Mm
		1145497 VINC_MOUSE (1-1134): 0: 811: 90.65		PAXI_MOUSE (258-395): 7.76e-27: 115: 25.90
+	Mm
		1145496 VINC_MOUSE (1-1134): 0: 811: 90.65		PDLI5_MOUSE (62-334): 6.71e-10: 63.5: 11.03
+	Ce
		587390 VINC_CAEEL (1-1132): 0: 674: 26.08		PXL1_CAEEL (249-396): 8.17e-29: 119: 23.49
+	Dm
		220705 VINC_DROME (1-933): 5.44e-126: 411: 28.23		Q9VIX2_DROME (248-396): 1.45e-31: 129: 27.33
+	Dm
		220698 VINC_DROME (1-933): 5.44e-126: 411: 28.23		Q2PDT4_DROME (248-396): 6.87e-31: 127: 27.33
+	Dm
		220702 VINC_DROME (1-933): 5.44e-126: 411: 28.23		Q8INW7_DROME (248-396): 1.24e-30: 126: 27.33
+	Hs
		716799 CTNA1_HUMAN (5-899): 1.05e-65: 241: 15.48		LIMD1_HUMAN (1-475): 1.08e-69: 236: 25.36
+	Hs
		640744 CTNA2_HUMAN (5-805): 6.26e-76: 272: 16.03		TES_HUMAN (141-457): 1.24e-56: 195: 19.09
+	Hs
		716742 CTNA1_HUMAN (5-899): 1.05e-65: 241: 15.48		LPP_HUMAN (3-475): 1.2e-65: 224: 38.82
+	Dm
		716606 CTNA_DROME (5-874): 5.84e-64: 236: 13.22		AJUBA_DROME (7-475): 9.64e-63: 218: 26.64
+	Hs
		716798 CTNA1_HUMAN (5-899): 1.05e-65: 241: 15.48		TES_HUMAN (141-457): 1.24e-56: 195: 19.09
+	Hs
		716782 CTNA1_HUMAN (5-899): 1.05e-65: 241: 15.48		PDLI7_HUMAN (111-473): 4.43e-25: 109: 13.77
+	Hs
		716693 CTNA1_HUMAN (5-899): 1.05e-65: 241: 15.48		ZYX_HUMAN (91-467): 2.51e-15: 80.4: 18.02