HitPredict

Interactor 1: RD21L (A2AU37)
Double-strand-break repair protein rad21-like protein 1
Gene: Rad21l1

Interactor 2: SMC3 (Q9CW03)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Mad member-interacting protein 1)
Gene: SMC3

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	24797475
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Rad21_Rec8~SMC_N, Rad21_Rec8_N~SMC_N
Common GO terms	GO:0000800 - lateral element GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0008278 - cohesin complex GO:0030893 - meiotic cohesin complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 552 Mm			1 1217
+	Xl
		1150103 Q6DCL7_XENLA (1-550): 0: 525: 41.24		Q8AW91_XENLA (1-1217): 1.43e-126: 421: 96.80
+	Hs
		224554 RAD21_HUMAN (1-550): 0: 525: 40.41		SMC3_HUMAN (1-1217): 8.01e-126: 419: 99.92
+	Xl
		292746 RAD21_XENLA (1-552): 1.56e-178: 519: 40.79		Q8AW91_XENLA (1-1217): 1.43e-126: 421: 96.80
+	Mm
		1142822 RAD21_MOUSE (1-550): 7.47e-178: 517: 39.94		SMC3_MOUSE (1-1217): 5.4e-126: 419: 100.00
+	Xl
		292737 RAD21_XENLA (1-552): 1.56e-178: 519: 40.79		SMC3_XENLA (1-1217): 8.79e-124: 413: 95.81
+	Mm
		57598 RD21L_MOUSE (1-552): 0: 630: 100.00		SMC1A_MOUSE (2-1211): 4.06e-79: 286: 16.21
+	Mm
		57597 RD21L_MOUSE (1-552): 0: 630: 100.00		SMC1B_MOUSE (2-1217): 2.83e-70: 259: 14.35
+	Hs
		224434 RAD21_HUMAN (1-550): 0: 525: 40.41		SMC1A_HUMAN (2-1211): 6.15e-79: 286: 16.21
+	Hs
		224536 RAD21_HUMAN (1-550): 0: 525: 40.41		SMC4_HUMAN (1-1206): 1.06e-77: 283: 17.34
+	Mm
		1142821 RAD21_MOUSE (1-550): 7.47e-178: 517: 39.94		SMC1A_MOUSE (2-1211): 4.06e-79: 286: 16.21
+	Hs
		224479 RAD21_HUMAN (1-550): 0: 525: 40.41		SMC1B_HUMAN (2-1217): 2.15e-74: 272: 14.64
+	Hs
		224250 RAD21_HUMAN (1-550): 0: 525: 40.41		SMC2_HUMAN (1-1217): 7.43e-73: 267: 19.14
+	Xl
		292726 RAD21_XENLA (1-552): 1.56e-178: 519: 40.79		SMC1A_XENLA (2-1211): 1.36e-72: 266: 15.97
+	Mm
		1142818 RAD21_MOUSE (1-550): 7.47e-178: 517: 39.94		SMC1B_MOUSE (2-1217): 2.83e-70: 259: 14.35
+	Hs
		304460 REC8_HUMAN (1-550): 5.03e-116: 356: 17.89		SMC3_HUMAN (1-1217): 8.01e-126: 419: 99.92
+	Sp
		193874 REC8_SCHPO (1-544): 6.73e-115: 353: 15.65		SMC3_SCHPO (1-1212): 9.34e-90: 317: 38.94
+	Hs
		304438 REC8_HUMAN (1-550): 5.03e-116: 356: 17.89		SMC1A_HUMAN (2-1211): 6.15e-79: 286: 16.21
+	Hs
		304446 REC8_HUMAN (1-550): 5.03e-116: 356: 17.89		SMC1B_HUMAN (2-1217): 2.15e-74: 272: 14.64
+	Sp
		293281 REC8_SCHPO (1-544): 6.73e-115: 353: 15.65		SMC1_SCHPO (2-1204): 3.23e-71: 262: 14.79
+	Mm
		1207969 REC8_MOUSE (1-549): 2.2e-114: 353: 17.84		SMC1B_MOUSE (2-1217): 2.83e-70: 259: 14.35