HitPredict

Interactor 1: PTPRA (P18433)
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)
Gene: PTPRA

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	28065597
Identification Methods	ubiquitin reconstruction
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0008286 - insulin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 583
+	Hs
		617042 PTPRE_HUMAN (130-802): 0: 836: 66.81		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Mm
		828096 PTPRE_MOUSE (107-802): 0: 827: 65.05		SHC1_MOUSE (1-583): 0: 527: 94.51
+	Hs
		208991 PTPRA_HUMAN (1-802): 0: 1040: 100.00		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		577024 PTPRA_HUMAN (1-802): 0: 1040: 100.00		SHB_HUMAN (369-579): 2.01e-41: 158: 20.63
+	Hs
		576988 PTPRA_HUMAN (1-802): 0: 1040: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		577009 PTPRA_HUMAN (1-802): 0: 1040: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Mm
		69652 PTPRS_MOUSE (5-799): 0: 930: 38.96		ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86
+	Mm
		574006 PTPRA_MOUSE (1-802): 0: 1003: 90.69		GRB2_MOUSE (482-578): 3.54e-15: 76.8: 30.48
+	Hs
		489988 PTPRF_HUMAN (4-799): 0: 894: 40.52		SH2D3_HUMAN (333-582): 8.25e-40: 157: 23.55
+	Hs
		616962 PTPRD_HUMAN (38-799): 0: 897: 40.50		BMX_HUMAN (341-582): 1.11e-38: 153: 19.69
+	Hs
		617047 PTPRE_HUMAN (130-802): 0: 836: 66.81		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		655375 PTPRK_HUMAN (14-794): 0: 757: 32.41		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		146925 PTPRT_HUMAN (51-795): 0: 778: 31.14		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		548649 PTN6_HUMAN (504-796): 1.16e-112: 357: 32.47		VAV_HUMAN (163-578): 1.81e-54: 200: 12.25
+	Hs
		655223 PTN6_HUMAN (504-796): 1.16e-112: 357: 32.47		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		557617 PTN4_HUMAN (515-793): 2.43e-103: 341: 33.80		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		655218 PTN4_HUMAN (515-793): 2.43e-103: 341: 33.80		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		924529 PTPRJ_HUMAN (516-797): 1.76e-118: 390: 38.87		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		665853 PTN6_HUMAN (504-796): 1.16e-112: 357: 32.47		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		663972 PTN4_HUMAN (515-793): 2.43e-103: 341: 33.80		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48