HitPredict

Interactor 1: AP2A2 (P18484)
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)
Gene: AP2A2

Interactor 2: TAU (P19332)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: Mapt

Species: Rattus norvegicus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	32357304
Identification Methods	cross-linking study
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0044877 - protein-containing complex binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 938 Rn			1 752
+	Rn
		94239 Q66HM2_RAT (1-938): 0: 890: 99.57		F1LST4_RAT (1-751): 5.68e-95: 314: 99.87
+	Hs
		302095 AP2A2_HUMAN (1-938): 0: 872: 96.06		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Mm
		497920 AP2A1_MOUSE (1-938): 0: 830: 77.84		TAU_MOUSE (1-752): 1.92e-82: 279: 89.52
+	Hs
		321471 AP2A1_HUMAN (1-938): 0: 834: 78.37		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Rn
		1144064 Q66HM2_RAT (1-938): 0: 890: 99.57		SYNJ1_RAT (328-740): 1.95e-12: 73.2: 12.80
+	Rn
		581970 AP2B1_RAT (36-933): 0: 628: 16.58		TAU_RAT (1-752): 2.4e-95: 314: 100.00
+	Rn
		94193 AP2B1_RAT (36-933): 0: 628: 16.58		F1LST4_RAT (1-751): 5.68e-95: 314: 99.87
+	Mm
		498136 AP2B1_MOUSE (36-933): 0: 627: 16.58		TAU_MOUSE (1-752): 1.92e-82: 279: 89.52
+	Hs
		203194 AP2A1_HUMAN (1-938): 0: 834: 78.37		SYNJ1_HUMAN (395-731): 7.71e-09: 61.6: 13.27
+	Hs
		496926 AP1B1_HUMAN (36-935): 0: 631: 16.99		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		496790 AP2B1_HUMAN (36-933): 0: 628: 16.58		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		212589 AP1G1_HUMAN (1-823): 0: 610: 24.70		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		497722 COPG2_HUMAN (18-930): 0: 588: 14.02		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		497899 COPG1_HUMAN (18-930): 0: 580: 13.59		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		1014106 AP1B1_HUMAN (36-935): 0: 631: 16.99		CABIN_HUMAN (103-561): 3.85e-12: 72.2: 12.26
+	Hs
		926047 AP2B1_HUMAN (36-933): 0: 628: 16.58		MAGL2_HUMAN (19-689): 6.16e-10: 65.1: 8.17
+	Hs
		203223 AP1B1_HUMAN (36-935): 0: 631: 16.99		SYNJ1_HUMAN (395-731): 7.71e-09: 61.6: 13.27
+	Hs
		203219 AP2B1_HUMAN (36-933): 0: 628: 16.58		SYNJ1_HUMAN (395-731): 7.71e-09: 61.6: 13.27
+	Hs
		150164 AP3D1_HUMAN (11-478): 2.19e-33: 141: 23.51		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86