Protein: IDHP
Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)

Gene: IDHP, IDH2
Organism: Homo sapiens
Interactions: 175
UniProt ID: P48735

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004450 - isocitrate dehydrogenase (NADP+) activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005777 - peroxisome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

877300

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

2

2

Small-scale

0.768

High

877396

KCMF1
E3 ubiquitin-protein ligase KCMF1

3

0

High-throughput

0.638

High

877394

S39A9
Zinc transporter ZIP9

2

0

High-throughput

0.602

High

529327

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.601

High

241053

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

877310

TERA
Transitional endoplasmic reticulum ATPase

2

5

High-throughput

0.571

High

443261

CDK1
Cyclin-dependent kinase 1

1

3

Small-scale

0.561

High

877306

PLK1
Serine/threonine-protein kinase PLK1

1

2

Small-scale

0.561

High

877356

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

877407

KIF3A
Kinesin-like protein KIF3A

1

1

High-throughput

0.536

High

274501

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

388166

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

563409

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

571571

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.513

High

866611

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

877309

SNAA
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.513

High

877330

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.513

High

877342

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

877352

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

877363

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

0

High-throughput

0.513

High

877364

GLMP
Glycosylated lysosomal membrane protein

1

0

High-throughput

0.513

High

877369

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.513

High

877379

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.513

High

877387

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

877388

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.513

High

877389

ANLN
Anillin

1

0

High-throughput

0.513

High

877390

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

877412

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

830329

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

406875

MAS
Proto-oncogene Mas

1

2

High-throughput

0.489

High

572909

INSRR
Insulin receptor-related protein

1

2

High-throughput

0.489

High

733305

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.489

High

877303

CEBPD
CCAAT/enhancer-binding protein delta

1

1

High-throughput

0.489

High

877345

KDM4D
Lysine-specific demethylase 4D

1

1

High-throughput

0.489

High

877355

FNDC5
Fibronectin type III domain-containing protein 5

1

2

High-throughput

0.489

High

877384

KDM4C
Lysine-specific demethylase 4C

1

1

High-throughput

0.489

High

877410

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

877406

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

279694

CISY
Citrate synthase, mitochondrial

1

3

High-throughput

0.479

High

362961

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

411563

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

470917

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

476117

ANXA5
Annexin A5

1

2

High-throughput

0.479

High

555949

CADH1
Cadherin-1

1

2

Small-scale

0.479

High

623186

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

667635

CDK2
Cyclin-dependent kinase 2

1

3

High-throughput

0.479

High

698480

CALX
Calnexin

1

3

High-throughput

0.479

High

717402

PDIA3
Protein disulfide-isomerase A3

1

2

High-throughput

0.479

High

749872

KINH
Kinesin-1 heavy chain

1

1

High-throughput

0.479

High

760873

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.479

High

788867

TGFR2
TGF-beta receptor type-2

1

1

High-throughput

0.479

High

877308

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

3

High-throughput

0.479

High

877313

RHOA
Transforming protein RhoA

1

1

High-throughput

0.479

High

877315

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

1

High-throughput

0.479

High

877317

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.479

High

877321

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

877324

CDC20
Cell division cycle protein 20 homolog

1

2

Small-scale

0.479

High

877326

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

877332

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

877338

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

877340

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

2

Small-scale

0.479

High

877347

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

877350

SND1
Staphylococcal nuclease domain-containing protein 1

1

2

High-throughput

0.479

High

877366

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

877373

ACON
Aconitate hydratase, mitochondrial

1

3

High-throughput

0.479

High

877377

ERP44
Endoplasmic reticulum resident protein 44

1

2

High-throughput

0.479

High

877392

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

2

Small-scale

0.479

High

877395

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

2

Small-scale

0.479

High

877397

CRNN
Cornulin

1

1

High-throughput

0.479

High

877399

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

877400

UBQL2
Ubiquilin-2

1

2

High-throughput

0.479

High

877401

PA2G4
Proliferation-associated protein 2G4

1

1

High-throughput

0.479

High

877402

FND3A
Fibronectin type-III domain-containing protein 3A

1

1

High-throughput

0.479

High

446134

PYGL
Glycogen phosphorylase, liver form

1

0

High-throughput

0.460

High

224656

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.458

High

258083

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.458

High

319517

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

349868

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

446390

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

489033

LKHA4
Leukotriene A-4 hydrolase

1

0

High-throughput

0.458

High

791177

SYUA
Alpha-synuclein

1

0

Small-scale

0.458

High

877304

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

877305

RM12
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.458

High

877307

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

877312

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

877329

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

877335

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

877336

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

877346

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

877358

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.458

High

877359

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

877360

RBCC1
RB1-inducible coiled-coil protein 1

1

0

High-throughput

0.458

High

877374

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

877380

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

877403

E41L3
Band 4.1-like protein 3

1

0

High-throughput

0.458

High

142301

PEX7
Peroxisomal targeting signal 2 receptor

1

3

High-throughput

0.445

High

538737

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

2

High-throughput

0.445

High

628610

CAP7
Azurocidin

1

2

High-throughput

0.445

High

877311

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.445

High

877341

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

877353

DND1
Dead end protein homolog 1

1

1

High-throughput

0.445

High

877361

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

2

High-throughput

0.445

High

877383

S2532
Solute carrier family 25 member 32

1

1

High-throughput

0.445

High

877391

S22AB
Solute carrier family 22 member 11

1

1

High-throughput

0.445

High

877393

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

877411

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

2

High-throughput

0.445

High

128499

RN103
E3 ubiquitin-protein ligase RNF103

1

1

High-throughput

0.437

High

258248

TRI13
E3 ubiquitin-protein ligase TRIM13

1

2

High-throughput

0.437

High

353099

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

588171

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

694894

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

767668

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

877314

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

877327

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.437

High

877334

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

877339

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

1

High-throughput

0.437

High

877349

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

877368

RN185
E3 ubiquitin-protein ligase RNF185

1

4

High-throughput

0.437

High

877375

RNF5
E3 ubiquitin-protein ligase RNF5

1

4

High-throughput

0.437

High

877385

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

970

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

369166

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

877323

MFGM
Lactadherin

1

0

High-throughput

0.426

High

877328

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

877331

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

0

Small-scale

0.426

High

877344

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.426

High

877348

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

0

Small-scale

0.426

High

877378

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

877398

CPNE7
Copine-7

1

0

High-throughput

0.426

High

877405

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.426

High

184007

S22A1
Solute carrier family 22 member 1

1

1

High-throughput

0.407

High

877302

CXCR3
C-X-C chemokine receptor type 3

1

2

High-throughput

0.407

High

877316

RAE1L
mRNA export factor RAE1

1

2

High-throughput

0.407

High

877320

TAGL
Transgelin

1

1

High-throughput

0.407

High

877357

SPX3
Sugar phosphate exchanger 3

1

2

High-throughput

0.407

High

854519

S15A1
Solute carrier family 15 member 1

2

0

High-throughput

0.313

High

105552

APRIO
Alternative prion protein

2

0

High-throughput

0.305

High

325305

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

754010

CD80
T-lymphocyte activation antigen CD80

1

0

High-throughput

0.279

Low

773822

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

877318

HXC5
Homeobox protein Hox-C5

1

0

High-throughput

0.279

Low

877322

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.279

Low

877337

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

877354

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

877367

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

877372

TECTB
Beta-tectorin

1

0

High-throughput

0.279

Low

877376

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

877404

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

877408

NGN3
Neurogenin-3

1

0

High-throughput

0.279

Low

877409

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

65716

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.249

Low

223511

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

1

0

High-throughput

0.249

Low

377454

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

405897

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.249

Low

458329

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.249

Low

471791

RU2B
U2 small nuclear ribonucleoprotein B''

1

0

High-throughput

0.249

Low

877301

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

877325

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.249

Low

877333

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.249

Low

877343

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.249

Low

877351

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

877365

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

0

High-throughput

0.249

Low

877370

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

877371

RN170
E3 ubiquitin-protein ligase RNF170

1

0

High-throughput

0.249

Low

877381

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.249

Low

877382

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

191884

MAGB3
Melanoma-associated antigen B3

1

0

High-throughput

0.232

Low

261124

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

330075

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

429512

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

598704

ANFB
Natriuretic peptides B

1

0

High-throughput

0.232

Low

877319

E2F1
Transcription factor E2F1

1

0

High-throughput

0.232

Low

877362

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low

877386

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025