HitPredict

Interactor 1: KALRN (A2CG49)
Kalirin (EC 2.7.11.1) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain)
Gene: KALRN

Interactor 2: AGAP2 (Q3UHD9)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE)
Gene: AGAP2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	28706196
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~fn3, Ras~fn3, Ank_2~I-set, ArfGap~PH, PH~Ras, Ank_2~Pkinase, Pkinase~Ras, Ras~RhoGEF, Ank_2~SH3_1
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0046872 - metal ion binding and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2964 Mm			1 1186
+	Mm
		1002014 TRIO_MOUSE (4-2954): 0: 2079: 60.05		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		57849 KALRN_MOUSE (1-2964): 0: 2415: 100.00		Q5F258_MOUSE (932-1139): 4.8e-72: 258: 32.88
+	Mm
		57855 KALRN_MOUSE (1-2964): 0: 2415: 100.00		GIT1_MOUSE (932-1139): 6.25e-72: 258: 32.88
+	Mm
		82757 B9EKJ1_MOUSE (123-1917): 1.7e-90: 333: 12.03		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		561159 SPTN1_MOUSE (123-1985): 8.08e-90: 330: 11.90		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		1112587 Q68FG2_MOUSE (15-1589): 3.07e-87: 322: 12.35		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		1112582 SPTB2_MOUSE (83-1591): 9.52e-85: 313: 12.83		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		1112660 MACF1_MOUSE (519-1526): 5.74e-12: 74.7: 10.93		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		1193579 SESD1_MOUSE (160-504): 1.49e-22: 107: 21.08		ASAP1_MOUSE (61-401): 7.43e-09: 62.2: 16.72