HitPredict

Interactor 1: KALRN (A2CG49)
Kalirin (EC 2.7.11.1) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain)
Gene: KALRN

Interactor 2: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	28706196, 27507650, 28671696, 19455133
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PDZ~fn3, PH~SH3_1, RhoGEF~SH3_1, Guanylate_kin~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0014069 - postsynaptic density GO:0035176 - social behavior GO:0098978 - glutamatergic synapse GO:0099645 - neurotransmitter receptor localization to postsynaptic specialization membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2964 Mm			1 724
+	Mm
		57873 KALRN_MOUSE (1-2964): 0: 2415: 100.00		DLG2_MOUSE (234-473): 4.91e-17: 87.8: 21.95
+	Hs
		279898 TRIO_HUMAN (4-2954): 0: 2090: 59.95		PALS2_HUMAN (22-193): 2.91e-13: 75.1: 15.52
+	Mm
		561163 SPTN1_MOUSE (123-1985): 8.08e-90: 330: 11.90		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		1143324 SPTB2_MOUSE (83-1591): 9.52e-85: 313: 12.83		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		1143380 DAPK1_MOUSE (2645-2914): 5.42e-61: 234: 40.65		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		1143373 SESD1_MOUSE (160-504): 1.49e-22: 107: 21.08		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		1143539 MACF1_MOUSE (519-1526): 5.74e-12: 74.7: 10.93		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		251106 DYST_MOUSE (607-1981): 2.05e-09: 66.2: 10.01		CSKP_MOUSE (6-381): 1.58e-20: 99: 14.43
+	Ce
		103468 TTN1_CAEEL (2425-2539): 4.06e-10: 68.6: 35.35		DLG1_CAEEL (131-395): 3.83e-14: 78.6: 18.71