HitPredict

Interactor 1: ATF3 (P18847)
Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
Gene: ATF3

Interactor 2: DDIT3 (P35638)
DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153)
Gene: DDIT3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 0.60 0.759

The method score is based on:

Property Details
Experiments 27107012, 29997244, 26264872, 23661758, 8622660, 33961781, 20102225, unassigned1913, 32814053, 20211142
Identification Methods two hybrid, fluorescent resonance energy transfer, affinity chromatography technology, pull down, peptide array, barcode fusion genetics two hybrid, luminescence based mammalian interactome mapping, split luciferase complementation, protein complementation assay, mammalian protein protein interaction trap and 3 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
and 11 others

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Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 181
Hs

1 169
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Last updated: 15 Jul 2024